{"id":"W2893415830","doi":"10.3389/fgene.2018.00410","title":"Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer’s Disease Development","year":2018,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Medpace; Biogen; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Biology; Genetic association; Disease; Herpes simplex virus; Alzheimer's disease; Dementia; Genetics; Gene; Virus; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162984,0.0004253148,0.0004650366,0.0009367976,0.0003016375,0.000641135,0.0002862648,0.0004666863,0.002995539],"category_scores_gemma":[0.001818581,0.0001915372,0.00070176,0.001078025,0.0003944096,0.0003139827,0.0004470618,0.0006215376,0.0003148396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084494,"about_ca_system_score_gemma":0.0002136175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001650958,"about_ca_topic_score_gemma":0.001477996,"domain_scores_codex":[0.9994962,0.0001563981,0.00003377795,0.0001813364,0.00007234186,0.00005998598],"domain_scores_gemma":[0.9989807,0.000361216,0.0003604038,0.0001159187,0.00009538212,0.0000864196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001111269,0.0001751793,0.9314191,0.0003458625,0.002074445,0.0005431903,0.0001744022,0.0007246275,0.02544348,0.001202638,0.001505807,0.03527999],"study_design_scores_gemma":[0.00002763177,0.0001443112,0.9917596,0.00002870844,0.0004466583,0.0005484383,0.00008760195,0.0008546252,0.001513013,0.001760053,0.002816296,0.00001311931],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697567,0.0186399,0.005099803,0.0009984652,0.0001673982,0.00003115246,0.00145816,0.00009591571,0.003752544],"genre_scores_gemma":[0.9922974,0.004298819,0.001710116,0.0003676558,0.0001164993,0.00002275741,0.0005111375,0.00001172183,0.0006638493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002995539,"threshold_uncertainty_score":0.01002109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875490237934107,"score_gpt":0.3164829326219553,"score_spread":0.2777280302426143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}