{"id":"W2893415830","doi":"10.3389/fgene.2018.00410","title":"Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer’s Disease Development","year":2018,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Medpace; Biogen; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Biology; Genetic association; Disease; Herpes simplex virus; Alzheimer's disease; Dementia; Genetics; Gene; Virus; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000549834,0.0001899617,0.0003574877,0.0003023812,0.0001717461,0.00003129009,0.00009341809,0.00007087864,0.00001092458],"category_scores_gemma":[0.0008010324,0.0001716794,0.00003931976,0.0002398556,0.0001177044,0.00003253734,0.0001530048,0.00009813893,0.00004938817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000554627,"about_ca_system_score_gemma":0.0003806104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000031191,"about_ca_topic_score_gemma":0.000006757039,"domain_scores_codex":[0.9983891,0.0001462609,0.0002704653,0.0003289942,0.0004033327,0.0004619086],"domain_scores_gemma":[0.9988582,0.0001739529,0.00009092252,0.0002434779,0.0002034381,0.0004300274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003443459,0.0001896195,0.9838139,0.00003028957,0.007207457,0.0001173099,0.0007397628,0.000002199283,0.0001102553,0.00000495515,0.002157764,0.002183046],"study_design_scores_gemma":[0.001831629,0.000293865,0.9886372,0.00009252213,0.0007707481,7.690505e-7,0.0004223575,0.00005622573,0.002999044,0.0006617373,0.004072877,0.0001609925],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8840044,0.1115092,0.001305073,0.001850019,0.0002842569,0.0009528898,0.00003618631,0.00003014048,0.00002783805],"genre_scores_gemma":[0.9865362,0.002032064,0.01056004,0.0004725101,0.00004786051,0.0001300685,0.00004818376,0.00002638586,0.0001466567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094771,"threshold_uncertainty_score":0.7000883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875490237934107,"score_gpt":0.3164829326219553,"score_spread":0.2777280302426143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}