{"id":"W2893494891","doi":"10.1002/path.5171","title":"The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis","year":2018,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Barncancerfonden; Lunds Universitet; Crafoordska Stiftelsen; Cancerfonden","keywords":"Homeobox; Biology; Wnt signaling pathway; Cancer research; Cell biology; Internal medicine; Gene; Genetics; Gene expression; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005772837,0.0001003178,0.0001320131,0.00003225323,0.0002384088,0.00001506847,0.0001605284,0.00009351698,0.000001954927],"category_scores_gemma":[0.0000310395,0.00004995504,0.0000278243,0.0000373058,0.0004306551,0.000003125058,0.00007872303,0.0001411389,9.350026e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001375234,"about_ca_system_score_gemma":0.00006075081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001620738,"about_ca_topic_score_gemma":0.0006325463,"domain_scores_codex":[0.9992499,0.0001500672,0.000251357,0.0001011468,0.00007683352,0.0001706813],"domain_scores_gemma":[0.9995852,0.0000199978,0.0001779151,0.0001074973,0.00006076402,0.00004859629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003388314,0.00003628812,0.01379447,0.00001172493,0.00009006088,0.00008871964,0.0013294,0.000008708781,0.9694796,0.00006890841,0.0004344338,0.01431885],"study_design_scores_gemma":[0.001980339,0.002223967,0.3393767,0.0001139177,0.0001044432,0.003649103,0.001557293,0.00001274066,0.607625,0.001029612,0.04198314,0.0003437408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950032,0.004083143,0.00008863631,0.0005586567,0.00006210068,0.00008680623,0.00000149037,0.000001504503,0.0001144186],"genre_scores_gemma":[0.9984408,0.0009084988,0.0001755207,0.0001146096,0.0001821742,0.000004110595,0.000001276604,0.000008914398,0.0001641058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3618546,"threshold_uncertainty_score":0.2037107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007109610845790625,"score_gpt":0.2372337000880428,"score_spread":0.2301240892422522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}