{"id":"W2893496195","doi":"10.3390/metabo8040059","title":"A Framework for Development of Useful Metabolomic Biomarkers and Their Effective Knowledge Translation","year":2018,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Waterloo","funders":"","keywords":"Metabolomics; Biomarker; Biomarker discovery; Medicine; Computer science; Data science; Bioinformatics; Proteomics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08050992,0.002841794,0.001602368,0.008837137,0.004633842,0.01529762,0.006172387,0.01130893,0.009721023],"category_scores_gemma":[0.05176893,0.001969506,0.003230297,0.003836228,0.01942352,0.01879174,0.01468385,0.008181867,0.005923857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009502672,"about_ca_system_score_gemma":0.03281672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008851035,"about_ca_topic_score_gemma":0.006236094,"domain_scores_codex":[0.9605514,0.02358821,0.005015543,0.003158523,0.00635429,0.001332072],"domain_scores_gemma":[0.9511915,0.02491132,0.004168613,0.006086112,0.01046019,0.003182301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00002965302,0.0001106293,0.0003214864,0.0004590177,0.00002090469,0.0003681055,0.00100988,0.002181895,0.0005695688,0.9585725,0.004841649,0.03151479],"study_design_scores_gemma":[0.00005342245,0.0001470615,0.0002996315,0.001229942,0.00002573925,0.0002512968,0.0008518036,0.007046533,0.0008915204,0.8739573,0.1151537,0.00009208467],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.001612297,0.002161293,0.9100427,0.05066372,0.0005605864,0.001843724,0.0003422968,0.0007330817,0.03204036],"genre_scores_gemma":[0.01991011,0.001673082,0.9709067,0.002317373,0.0002989054,0.001785867,0.0002878866,0.00007884536,0.002741332],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.08050992,"threshold_uncertainty_score":0.4257822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242787283194873,"score_gpt":0.3042749491803406,"score_spread":0.2718470763483919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}