{"id":"W2893535784","doi":"10.1182/blood-2018-07-863431","title":"T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Biology; T-cell receptor; CD8; T cell; Severe combined immunodeficiency; Immunodeficiency; Wiskott–Aldrich syndrome; Immunology; Wiskott–Aldrich syndrome protein; Molecular biology; Cell biology; Actin cytoskeleton; Antigen; Cell; Cytoskeleton; Immune system; In vivo; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851747,0.0002154037,0.0002614444,0.0001669853,0.0003570104,0.00002363276,0.0002856657,0.0001585445,0.0001388261],"category_scores_gemma":[0.00006328113,0.0001818531,0.00007872334,0.0003221026,0.0003199429,0.0001444626,0.00004919154,0.0001795499,0.0002364741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000202933,"about_ca_system_score_gemma":0.00009081402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005789924,"about_ca_topic_score_gemma":0.00001107648,"domain_scores_codex":[0.9986995,0.00005868142,0.0003416632,0.0003334341,0.00005030206,0.0005164428],"domain_scores_gemma":[0.9991977,0.000101846,0.0001415893,0.0003543701,0.0001986783,0.000005833394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006097647,0.05656587,0.4135522,0.0003490594,0.0008154441,0.00001017958,0.01029906,0.0001392134,0.4945286,0.006089818,0.001134672,0.01041824],"study_design_scores_gemma":[0.06980787,0.006061235,0.7940831,0.000147552,0.0003438223,0.000009260788,0.0008308838,0.00003001963,0.1143007,0.0007588196,0.01248686,0.001139815],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927759,0.004066458,0.0002248796,0.00002940338,0.0003693374,0.0007132831,0.00005056773,0.00006877061,0.00170141],"genre_scores_gemma":[0.9986922,0.00001020414,0.00008877274,0.000111514,0.00000403491,0.00009988254,0.0004206022,0.00002708203,0.0005457307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3805309,"threshold_uncertainty_score":0.7415755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004452480612805064,"score_gpt":0.1997276932744777,"score_spread":0.1952752126616726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}