{"id":"W2893535784","doi":"10.1182/blood-2018-07-863431","title":"T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Biology; T-cell receptor; CD8; T cell; Severe combined immunodeficiency; Immunodeficiency; Wiskott–Aldrich syndrome; Immunology; Wiskott–Aldrich syndrome protein; Molecular biology; Cell biology; Actin cytoskeleton; Antigen; Cell; Cytoskeleton; Immune system; In vivo; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057104,0.001265125,0.0004274896,0.001413537,0.0006859432,0.0004152362,0.0003403057,0.0009122386,0.003300742],"category_scores_gemma":[0.0008804381,0.0002568352,0.0003595628,0.0005822989,0.000471972,0.0002580071,0.0003317084,0.0006350499,0.0003521212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889531,"about_ca_system_score_gemma":0.0001898682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007699439,"about_ca_topic_score_gemma":0.0005243127,"domain_scores_codex":[0.9997407,0.0000295693,0.00003775366,0.0000807785,0.00005534397,0.00005585149],"domain_scores_gemma":[0.9996736,0.0001133619,0.00006701359,0.0000209924,0.00003340589,0.00009173151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00154978,0.0003595153,0.5574129,0.0001404041,0.0001807461,0.3005682,0.00083146,0.0005450544,0.1230759,0.0005606027,0.00111049,0.01366493],"study_design_scores_gemma":[0.000134515,0.0009224939,0.4075935,0.00006073388,0.0002671448,0.566985,0.000339651,0.002163909,0.01843231,0.0003765854,0.002690012,0.00003412188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976783,0.0003059972,0.0004020288,0.00008861879,0.00001707976,0.00002783838,0.000161549,0.00005072378,0.001267724],"genre_scores_gemma":[0.9994296,0.00007286296,0.0001561344,0.00003759516,0.00001832422,0.000006731858,0.00008764944,0.000005545382,0.0001854718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003300742,"threshold_uncertainty_score":0.01104212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004452480612805064,"score_gpt":0.1997276932744777,"score_spread":0.1952752126616726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}