{"id":"W2893692730","doi":"10.1002/gcc.22685","title":"Clonal evolution through genetic bottlenecks and telomere attrition: Potential threats to in vitro data reproducibility","year":2018,"lang":"en","type":"review","venue":"Genes Chromosomes and Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Vetenskapsrådet; Barncancerfonden; Crafoordska Stiftelsen; Cancerfonden; Gunnar Nilssons Cancerstiftelse","keywords":"Telomere; Biology; Population; In vitro; Genetics; Cell culture; Attrition; Mutation; Genotype; Computational biology; DNA; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003004766,0.0004030178,0.000758648,0.00006024052,0.0001142026,0.00007408755,0.000365236,0.000360128,0.0000334458],"category_scores_gemma":[0.00007542652,0.0003762658,0.0001115445,0.0001711768,0.0001673568,0.00001041595,0.000937567,0.0001304509,0.000005071563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001067683,"about_ca_system_score_gemma":0.0004230003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004289229,"about_ca_topic_score_gemma":0.0004818045,"domain_scores_codex":[0.9967909,0.00007321389,0.0004828513,0.002111391,0.000176849,0.000364725],"domain_scores_gemma":[0.9978414,0.00001890339,0.0001599107,0.001741752,0.0001042882,0.0001338117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000840846,0.00006418837,0.0002435534,0.002632438,0.0001484226,0.00001290544,0.00002859957,0.000007543093,0.001873659,0.000009932296,0.007565462,0.9873292],"study_design_scores_gemma":[0.0003601594,0.0001503357,0.000539251,0.0007959805,0.0002915795,0.0001005563,0.00001574609,0.0000100023,0.0006458755,0.0001412172,0.9964423,0.0005070161],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01026733,0.98566,0.0001148195,0.0001649344,0.0005508221,0.0006925068,0.002509446,0.000007829956,0.00003237577],"genre_scores_gemma":[0.001510682,0.993022,0.0009761521,0.0001444422,0.002483384,0.0001921264,0.001415619,0.00005225063,0.0002033795],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888768,"threshold_uncertainty_score":0.9998689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05674702150957771,"score_gpt":0.3466215586735578,"score_spread":0.28987453716398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}