{"id":"W2893724706","doi":"10.1111/mmi.14139","title":"Sterol methyltransferase is required for optimal mitochondrial function and virulence in <i>Leishmania major</i>","year":2018,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Washington University in St. Louis; National Institutes of Health; National Institute of Allergy and Infectious Diseases; McMaster University; National Institute of Diabetes and Digestive and Kidney Diseases; School of Medicine; University of British Columbia","keywords":"Biology; Virulence; Leishmania; Sterol; Function (biology); Methyltransferase; Leishmania mexicana; Kinetoplastida; Microbiology; Genetics; Biochemistry; Parasite hosting; Protozoal disease; Cholesterol; Immunology; Methylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000656607,0.0002305935,0.0001629474,0.0001503589,0.00009742325,0.0002750517,0.0001198222,0.0001698965,0.0008051597],"category_scores_gemma":[0.0001369521,0.000105355,0.0001805979,0.0001135521,0.0001528813,0.0001205183,0.0001827356,0.0002226251,0.0005107117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705449,"about_ca_system_score_gemma":0.0002256055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009930477,"about_ca_topic_score_gemma":0.001244137,"domain_scores_codex":[0.9999192,0.00001254821,0.00001096176,0.00001601749,0.00002195605,0.0000192988],"domain_scores_gemma":[0.9998691,0.0000112995,0.00006357299,0.00001250107,0.00001924729,0.00002432153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004553003,0.000004954926,0.0003979205,0.00001772495,0.000002246122,0.00005031738,0.000008613224,0.00001182756,0.9988425,0.00003642232,0.00001513415,0.0005669079],"study_design_scores_gemma":[0.00001313399,0.0001868294,0.02916701,0.000011698,0.00002946116,0.001103748,0.00008757495,0.0004512129,0.965265,0.000106674,0.00356974,0.000007887023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962914,0.001025402,0.001386485,0.00009671167,0.000009996913,0.0000107025,0.0003650693,0.00006485451,0.0007494036],"genre_scores_gemma":[0.9973792,0.0003707605,0.0007700569,0.00002537479,0.00000374447,0.000006901685,0.0006727093,0.00002154948,0.0007498062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009930477,"threshold_uncertainty_score":0.002693534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692512299645833,"score_gpt":0.2891938975532255,"score_spread":0.2722687745567672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}