{"id":"W2893741908","doi":"10.1186/s40035-018-0127-7","title":"Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Meso Scale Diagnostics; Chongqing Medical University; Eisai; Weston Brain Institute; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Neuroimaging; Dementia; Alzheimer's Disease Neuroimaging Initiative; Medicine; Internal medicine; Biomarker; Pathology; Neuropathology; Tau protein; Neurology; Hyperintensity; Logistic regression; Cognitive decline; Correlation; Disease; Magnetic resonance imaging; Psychology; Alzheimer's disease; Oncology; Neuroscience; Biology; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100952,0.0006771874,0.0006470772,0.001797032,0.0006357667,0.0007769801,0.0004841455,0.000625044,0.0007496775],"category_scores_gemma":[0.003225521,0.0003190548,0.0005315137,0.001050223,0.0004234197,0.0004551785,0.0005640548,0.0004098858,0.0001533602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005519884,"about_ca_system_score_gemma":0.0005958547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01138536,"about_ca_topic_score_gemma":0.01036963,"domain_scores_codex":[0.9995753,0.0001273249,0.00005202624,0.00009685148,0.00009325198,0.00005514469],"domain_scores_gemma":[0.9990307,0.000184735,0.000409203,0.00005563227,0.0001135796,0.0002061479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008366038,0.00009981807,0.9939784,0.00004701614,0.0002034408,0.0002444532,0.0001447267,0.00008967897,0.0004264267,0.00002022627,0.0001438016,0.003765414],"study_design_scores_gemma":[0.00001403727,0.00008819476,0.9990671,0.00001081409,0.00005944115,0.0002085328,0.00009143793,0.0002105285,0.0000595802,0.000101143,0.00008521578,0.000003886884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980221,0.001369198,0.00005570249,0.00005988785,0.00001240662,0.0000103761,0.0002040515,0.000004901037,0.0002614968],"genre_scores_gemma":[0.9994015,0.00018303,0.00008668816,0.00002005172,0.000019165,0.000008703189,0.000162215,9.007722e-7,0.0001178185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01138536,"threshold_uncertainty_score":0.02263814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440264470037612,"score_gpt":0.2957879485794018,"score_spread":0.2713853038790257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}