{"id":"W2893817088","doi":"10.1016/j.ijpddr.2018.09.004","title":"Molecular and pharmacological characterization of an acetylcholine-gated chloride channel (ACC-2) from the parasitic nematode Haemonchus contortus","year":2018,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ontario Institute of Technology","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Haemonchus contortus; Biology; Acetylcholine receptor; Cholinergic; Biochemistry; Receptor; Acetylcholine; Ligand-gated ion channel; Chloride channel; Chemistry; Ion channel; Pharmacology; Endocrinology; Nematode","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026588,0.0002335227,0.0001465249,0.00009289278,0.0001049426,0.0001673533,0.0001774894,0.0003646135,0.0004242714],"category_scores_gemma":[0.0001749229,0.0000694563,0.0001894707,0.00009003254,0.000135352,0.0001403592,0.0000876356,0.0003173569,0.0001492315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892695,"about_ca_system_score_gemma":0.0001627069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112034,"about_ca_topic_score_gemma":0.00155308,"domain_scores_codex":[0.9999369,0.000007995928,0.000006059439,0.00001004863,0.00002754832,0.00001140429],"domain_scores_gemma":[0.9999106,0.00001596633,0.00002469465,0.000007171896,0.00001857327,0.00002297578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002969326,0.00001460155,0.0001358442,0.00001777966,0.000002322276,0.0000531469,0.000004981397,0.00003722501,0.9993827,0.00002046807,0.000008696704,0.0002925727],"study_design_scores_gemma":[0.0000495445,0.0008034001,0.02940914,0.00001272211,0.00003911309,0.001771161,0.00005505645,0.003061132,0.9613938,0.00005264537,0.00334045,0.00001184035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976774,0.0005375004,0.0008333818,0.00007784321,0.00001180741,0.00002933781,0.0002549816,0.00001128216,0.0005665756],"genre_scores_gemma":[0.9936633,0.0005820788,0.002749897,0.00006859634,0.00001224223,0.00002196307,0.001521887,0.000007824357,0.001372145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112034,"threshold_uncertainty_score":0.002227604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827251935931328,"score_gpt":0.3559404068579606,"score_spread":0.3376678874986473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}