{"id":"W2893919408","doi":"10.1016/j.taap.2018.09.034","title":"Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes","year":2018,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University","keywords":"Acetaminophen; Carbon monoxide; Chemistry; Pharmacology; Gene; Molecule; Biochemistry; Medicine; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475823,0.000717217,0.000326854,0.000544213,0.0002106817,0.0002138107,0.0003365842,0.0004696359,0.001847377],"category_scores_gemma":[0.0001047075,0.0001728186,0.0002525349,0.0001924677,0.0004254117,0.0003712481,0.000139946,0.001029289,0.0002723327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198342,"about_ca_system_score_gemma":0.0003055563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000542118,"about_ca_topic_score_gemma":0.001203427,"domain_scores_codex":[0.9998991,0.00001750113,0.000008600891,0.00002023873,0.00002306275,0.00003148368],"domain_scores_gemma":[0.9997773,0.00001333457,0.00009420238,0.00001933425,0.00002154527,0.00007438411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00216503,0.0004199323,0.0002221797,0.00006090883,0.00001638992,0.00006230448,0.00001392222,0.00007563653,0.9936321,0.0001116521,0.0001044494,0.00311552],"study_design_scores_gemma":[0.0002391285,0.00368405,0.005904037,0.00001526062,0.00007124419,0.0001476772,0.00005976292,0.0007527398,0.987308,0.0001358623,0.001670957,0.00001129719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956773,0.001333896,0.001416265,0.0003013192,0.00006743001,0.00003108964,0.0003212743,0.0001717626,0.000679605],"genre_scores_gemma":[0.991037,0.001546476,0.002238403,0.0001273972,0.00003880986,0.00007078056,0.0005501957,0.00003160314,0.004359225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847377,"threshold_uncertainty_score":0.006180108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007583791093400572,"score_gpt":0.2438108199174942,"score_spread":0.2362270288240936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}