{"id":"W2893975246","doi":"10.3389/fphar.2018.01149","title":"Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Calgary; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Serotonin; 5-HT2A receptor; Depression (economics); Serotonin transporter; Internal medicine; Serotonin Plasma Membrane Transport Proteins; 5-HT receptor; Receptor; Corticosterone; Endocrinology; Major depressive disorder; Psychology; Biomarker; Lipid raft; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263235,0.0003168206,0.0002784453,0.00037583,0.000153949,0.0001921183,0.0001309836,0.0002805914,0.0008420924],"category_scores_gemma":[0.0001076471,0.000128311,0.0001575531,0.000182082,0.0001862025,0.0001592013,0.0001181502,0.0004382927,0.0001858779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595149,"about_ca_system_score_gemma":0.00007243288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003569904,"about_ca_topic_score_gemma":0.0006702317,"domain_scores_codex":[0.9999052,0.00001929102,0.000008633652,0.00002694639,0.00002342461,0.00001648199],"domain_scores_gemma":[0.999909,0.000009130755,0.00003861644,0.000009907191,0.00001319022,0.00002005737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005174843,0.00009694922,0.005659703,0.00006751662,0.00002869752,0.0001282032,0.00003379776,0.00004345976,0.9893874,0.00004177635,0.00006253981,0.003932438],"study_design_scores_gemma":[0.00009287567,0.00351832,0.5714827,0.00005184585,0.0001723639,0.002158039,0.0003698382,0.002025492,0.417619,0.0003352613,0.00215189,0.00002240623],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935316,0.002314405,0.002899,0.0001087738,0.00003273661,0.00004534391,0.0002615541,0.00006692364,0.0007398234],"genre_scores_gemma":[0.9954128,0.0013,0.002083802,0.00008283342,0.00001430296,0.00007018553,0.0002943482,0.0000068187,0.0007349757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008420924,"threshold_uncertainty_score":0.002817094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07173660253828494,"score_gpt":0.3282939445230535,"score_spread":0.2565573419847685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}