{"id":"W2894123160","doi":"10.1053/j.gastro.2018.09.041","title":"Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency","year":2018,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"Daimler und Benz Stiftung; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Else Kröner-Fresenius-Stiftung; Care-for-Rare Foundation; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Scopus; Medicine; Exome sequencing; Inflammatory bowel disease; Internal medicine; Disease; Immunology; Mutation; Biology; Genetics; MEDLINE; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009053837,0.0001144078,0.0001026981,0.00007446063,0.00005690794,0.000009567292,0.00008958574,0.00007337234,0.00001437822],"category_scores_gemma":[0.00003912797,0.000103408,0.00001418291,0.00007561652,0.000233293,0.000007389523,0.0000876902,0.00008309695,0.000004819691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008982521,"about_ca_system_score_gemma":0.00001483508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003872806,"about_ca_topic_score_gemma":0.0004608226,"domain_scores_codex":[0.9992516,0.00007933482,0.0001679015,0.0001961924,0.00005261497,0.0002523786],"domain_scores_gemma":[0.9996077,0.000002948117,0.00006635962,0.0001802482,0.0001138714,0.00002891548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001345159,0.00006426365,0.9554982,0.000005795204,0.0000137329,0.000001321619,0.0001085951,0.000008276764,0.04161024,0.000006695115,0.00004028105,0.001297446],"study_design_scores_gemma":[0.002235236,0.00312754,0.9885279,0.00001091144,0.000006850249,0.00001273015,0.00005751666,0.00004962663,0.005700147,0.00001358451,0.000181027,0.00007696488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993092,0.00002553174,0.0002596924,0.00006852231,0.00004494439,0.0001400614,0.000002847919,0.000008331232,0.0001408532],"genre_scores_gemma":[0.9994027,0.000005435778,0.0002468835,0.000114771,0.0000295871,0.00000943038,0.0001643219,0.00001053592,0.0000163037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0359101,"threshold_uncertainty_score":0.4216856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003208432183738267,"score_gpt":0.190014269604306,"score_spread":0.1868058374205677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}