{"id":"W2894274457","doi":"10.1101/426577","title":"Slow transcriptional elongation causes embryonic lethality and perturbs kinetic coupling of long neural genes","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Wellcome Trust","keywords":"Cell biology; Embryonic stem cell; Biology; Elongation; RNA polymerase II; RNA splicing; Transcription (linguistics); Gene; Gene expression; Genetics; RNA; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268566,0.0006766962,0.0003133881,0.0004934563,0.0001157277,0.0003116139,0.0003274454,0.0003542107,0.001414456],"category_scores_gemma":[0.0002457139,0.0002471589,0.0003254706,0.0001993526,0.0003801234,0.000169916,0.0004385317,0.0008140404,0.000427983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052159,"about_ca_system_score_gemma":0.0001943769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004233981,"about_ca_topic_score_gemma":0.0006653729,"domain_scores_codex":[0.999705,0.00004439138,0.00004956181,0.000078274,0.00008851515,0.00003420344],"domain_scores_gemma":[0.9995753,0.00008085123,0.0001772033,0.00007113226,0.0000231714,0.00007236607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006624776,0.00001122096,0.0001968135,0.00001774673,0.000005339613,0.00007144378,0.000006833613,0.00009391591,0.9986417,0.0001179493,0.00002269051,0.0007482357],"study_design_scores_gemma":[0.00001172524,0.0001032228,0.003128647,0.000007557125,0.00001437976,0.0002111565,0.000009633473,0.0006584569,0.9943954,0.0000856472,0.001368744,0.000005427021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886309,0.001041102,0.007346032,0.0001019209,0.0000526286,0.00002523256,0.001097161,0.0002864853,0.001418528],"genre_scores_gemma":[0.9903954,0.0008538941,0.00383904,0.0000648437,0.00001637379,0.00005212872,0.0009695309,0.0002387277,0.003570193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414456,"threshold_uncertainty_score":0.004731774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765428683444449,"score_gpt":0.2481014369802269,"score_spread":0.2304471501457824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}