{"id":"W2894392153","doi":"10.3389/fmicb.2018.02300","title":"Efficient Production of Recombinant Protegrin-1 From Pichia pastoris, and Its Antimicrobial and in vitro Cell Migration Activity","year":2018,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Foshan University","keywords":"Pichia pastoris; Recombinant DNA; Antimicrobial; Escherichia coli; Antimicrobial peptides; Microbiology; Biology; Yeast; In vitro; Pichia; Cathelicidin; Fermentation; Biochemistry; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542914,0.0006043205,0.0004857278,0.0002592742,0.0001912014,0.0004747192,0.0003097021,0.0003684911,0.0003825816],"category_scores_gemma":[0.0001616031,0.0002002279,0.0003436638,0.000510748,0.0001534693,0.0002261873,0.0003032679,0.0006088435,0.0003364145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004169543,"about_ca_system_score_gemma":0.0001937375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009883025,"about_ca_topic_score_gemma":0.001365504,"domain_scores_codex":[0.9997794,0.00003716039,0.0000250976,0.00004449026,0.00007949132,0.00003426544],"domain_scores_gemma":[0.9999492,0.000007904128,0.00001714549,0.000008122966,0.000007047537,0.00001058037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005896678,0.00004121635,0.0001490896,0.0001198484,0.00001127651,0.00009511878,0.00002171976,0.0002476347,0.9967033,0.00006697153,0.00009469437,0.002390115],"study_design_scores_gemma":[0.00003054231,0.0003309813,0.003865094,0.00002441501,0.00006022302,0.000475064,0.0000411511,0.002294058,0.9831971,0.00006507335,0.009599954,0.00001631199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767095,0.006581747,0.01008308,0.0003327531,0.0001298602,0.0001470515,0.00295209,0.0003164659,0.002747533],"genre_scores_gemma":[0.9649585,0.003044483,0.02128365,0.00009506514,0.00002687165,0.0001464945,0.005156432,0.00005954081,0.005228851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883025,"threshold_uncertainty_score":0.003025174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005823471413492913,"score_gpt":0.1942862159232399,"score_spread":0.188462744509747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}