{"id":"W2894432049","doi":"10.1111/hae.13608","title":"Once‐weekly prophylaxis with 40 IU/kg nonacog beta pegol (N9‐GP) achieves trough levels of &gt;15% in patients with haemophilia B: Pooled data from the paradigm™ trials","year":2018,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Novo Nordisk","keywords":"Medicine; Haemophilia; Haemophilia B; BETA (programming language); Haemophilia A; Trough (economics); Internal medicine; Clinical trial; Pharmacology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00149338,0.0007736504,0.002021177,0.0003118717,0.0003073542,0.00009308735,0.001432055,0.0003621164,0.0008143202],"category_scores_gemma":[0.0008194258,0.0004003695,0.000212452,0.001186295,0.001389323,0.0005197708,0.0004761816,0.0007826015,0.0002679206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186153,"about_ca_system_score_gemma":0.0008278529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926845,"about_ca_topic_score_gemma":0.0008596684,"domain_scores_codex":[0.9933555,0.0007918241,0.001367675,0.001453616,0.001981607,0.001049796],"domain_scores_gemma":[0.9941964,0.000953317,0.0005853556,0.003358763,0.000503037,0.0004031045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0374448,0.005150693,0.8978018,0.0003729544,0.003201085,0.0006362641,0.003150261,0.000007438208,0.003527435,0.0003019794,0.01263076,0.03577459],"study_design_scores_gemma":[0.02051136,0.008608611,0.9577556,0.001045259,0.000906769,0.00002873159,0.0002491952,0.0001623916,0.006117863,0.0007257102,0.003237663,0.0006508111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831306,0.0006167484,0.00006168793,0.00847025,0.0002375117,0.004262845,0.001892751,0.00008583418,0.001241724],"genre_scores_gemma":[0.9938597,0.0000662263,0.001641159,0.0002751266,0.0009257876,0.0001131194,0.001188159,0.0001301724,0.001800562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0599539,"threshold_uncertainty_score":0.9998448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09907442327032728,"score_gpt":0.3392865823249818,"score_spread":0.2402121590546545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}