{"id":"W2894486342","doi":"10.1016/j.stem.2018.09.005","title":"Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; New York Stem Cell Foundation; Burroughs Wellcome Fund; Howard Hughes Medical Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Glenn Foundation for Medical Research; National Institutes of Health; Edward Mallinckrodt, Jr. Foundation; National Science Foundation","keywords":"Stem cell; Biology; Cell biology; Homeostasis; Cellular differentiation; Cell division; Cell; Compartment (ship); Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001008816,0.0003014938,0.0002283873,0.00005677941,0.0002051682,0.00007214679,0.0002818237,0.000248904,0.00034466],"category_scores_gemma":[9.688069e-7,0.0003029761,0.0001850005,0.0001039248,0.00005560677,0.00001126325,0.0001656548,0.0001547732,0.0004569132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005655413,"about_ca_system_score_gemma":0.00006934204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002713105,"about_ca_topic_score_gemma":0.00001995573,"domain_scores_codex":[0.9982716,0.0001033298,0.0003801018,0.0005934432,0.0002098992,0.0004416456],"domain_scores_gemma":[0.9989067,0.00002059677,0.0002135046,0.0005177742,0.0001450946,0.0001963759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003256456,0.0003435347,0.0001716937,0.00008378228,0.00003620327,0.000003164038,0.0003018467,0.00001007778,0.9651169,0.00001139323,0.03209318,0.001795722],"study_design_scores_gemma":[0.0006953516,0.0005090075,0.00002446342,0.000009896647,0.00006657909,0.000004949623,0.0003254944,0.003428848,0.9047452,0.00001961784,0.08983549,0.0003351442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525787,0.001455825,0.03352784,0.0000840905,0.0008887089,0.0003380264,0.0001000785,0.00004931531,0.01097747],"genre_scores_gemma":[0.9816771,0.0002723541,0.0002015378,0.000344764,0.0003017873,0.00002257566,0.0003469115,0.00006017317,0.01677276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06037168,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005981908169313319,"score_gpt":0.2056334796658832,"score_spread":0.1996515714965698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}