{"id":"W2894556354","doi":"10.1042/bsr20181605","title":"Structural and functional characterisation of the entry point to pyocyanin biosynthesis in <i>Pseudomonas aeruginosa</i> defines a new 3-deoxy-<scp>d</scp>-arabino-heptulosonate 7-phosphate synthase subclass","year":2018,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Biomolecular Interaction Centre, University of Canterbury; Marsden Fund; Maurice Wilkins Centre for Molecular Biodiscovery; Australian Synchrotron","keywords":"Shikimate pathway; Pyocyanin; Biosynthesis; Aromatic amino acids; Secondary metabolism; Shikimic acid; Biochemistry; ATP synthase; Phenazine; Pseudomonas aeruginosa; Biology; Chemistry; Stereochemistry; Amino acid; Enzyme; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000385309,0.0001965451,0.0002094651,0.0001218068,0.0001314769,0.00004470878,0.0001908012,0.0001202952,0.00001905277],"category_scores_gemma":[0.0009885661,0.0001434378,0.00009571009,0.0004521889,0.0002489334,0.00002295929,0.0002561414,0.00006597967,0.000003697088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002757841,"about_ca_system_score_gemma":0.0002232433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001669972,"about_ca_topic_score_gemma":0.0001570183,"domain_scores_codex":[0.9981928,0.00007245664,0.0004427299,0.0006256152,0.000361427,0.0003049368],"domain_scores_gemma":[0.9988449,0.00004080122,0.0003607167,0.0004663097,0.0001107841,0.0001764436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002255616,0.00002065571,0.06833159,0.000006266018,0.00001099921,0.00001132748,0.0000868018,0.00001488412,0.9281468,0.00001323654,0.002664854,0.0006700401],"study_design_scores_gemma":[0.0001128392,0.00005752911,0.2108426,0.00003840143,0.00001626295,0.0001711888,0.0000607176,0.000120248,0.7846904,0.00006017977,0.003743928,0.00008569918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982767,0.0001210444,0.0001629447,0.0005428627,0.0004348002,0.0002047388,0.00002485934,0.00001152429,0.0002205803],"genre_scores_gemma":[0.9982414,0.00005996906,0.0004078413,0.0003937143,0.0001312868,0.000009974254,0.00001994899,0.00001130019,0.0007245481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1434564,"threshold_uncertainty_score":0.5849225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107474122540763,"score_gpt":0.2217460749671825,"score_spread":0.2109986627131062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}