{"id":"W2894556354","doi":"10.1042/bsr20181605","title":"Structural and functional characterisation of the entry point to pyocyanin biosynthesis in <i>Pseudomonas aeruginosa</i> defines a new 3-deoxy-<scp>d</scp>-arabino-heptulosonate 7-phosphate synthase subclass","year":2018,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Biomolecular Interaction Centre, University of Canterbury; Marsden Fund; Maurice Wilkins Centre for Molecular Biodiscovery; Australian Synchrotron","keywords":"Shikimate pathway; Pyocyanin; Biosynthesis; Aromatic amino acids; Secondary metabolism; Shikimic acid; Biochemistry; ATP synthase; Phenazine; Pseudomonas aeruginosa; Biology; Chemistry; Stereochemistry; Amino acid; Enzyme; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006182941,0.000272879,0.0001944349,0.0001089253,0.0001050244,0.000304332,0.0001704026,0.0002382587,0.0005013585],"category_scores_gemma":[0.000154499,0.0001125961,0.0002725363,0.0001672454,0.0002118886,0.0001621362,0.0001631978,0.0004294321,0.0003816294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449779,"about_ca_system_score_gemma":0.0002101085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492388,"about_ca_topic_score_gemma":0.001103812,"domain_scores_codex":[0.9999263,0.00001009309,0.000004583068,0.00001556061,0.00002849854,0.00001501888],"domain_scores_gemma":[0.9998649,0.00002185208,0.00004073057,0.00001673503,0.00002032742,0.00003527526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003204154,0.00000933405,0.0004754939,0.00001204271,0.00000219904,0.00005426022,0.00002090695,0.00006279098,0.9984668,0.00003799055,0.00001278625,0.0008134583],"study_design_scores_gemma":[0.00001218797,0.0003113776,0.04021265,0.00000719541,0.00001973893,0.0006922736,0.0001377887,0.001569491,0.9533122,0.0001137022,0.003595188,0.00001616163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997664,0.0002028394,0.001398312,0.00003065324,0.00000344035,0.00001116318,0.0002680612,0.00002510499,0.0003964559],"genre_scores_gemma":[0.99536,0.0001847512,0.00202244,0.00002790809,0.000005334398,0.00001183341,0.001455821,0.00002844626,0.0009035066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492388,"threshold_uncertainty_score":0.002967417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107474122540763,"score_gpt":0.2217460749671825,"score_spread":0.2109986627131062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}