{"id":"W2894616721","doi":"10.1101/427385","title":"Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Clinical trial; Cohort; Medicine; Sample size determination; Disease; Randomization; Internal medicine; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09131086,0.0006354231,0.001815053,0.0007851124,0.0005889497,0.003514396,0.001797034,0.002687965,0.003059246],"category_scores_gemma":[0.3151345,0.0004399478,0.002759481,0.0009665834,0.004218173,0.002088344,0.001468627,0.004181753,0.000222668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001709732,"about_ca_system_score_gemma":0.002844766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002673082,"about_ca_topic_score_gemma":0.002047513,"domain_scores_codex":[0.8906862,0.09988133,0.001694866,0.004266244,0.002807697,0.0006637882],"domain_scores_gemma":[0.4834898,0.4806451,0.01605425,0.01246061,0.005095979,0.002254256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.007767939,0.000537293,0.3369019,0.002525329,0.01365626,0.001912088,0.002112565,0.2384155,0.002082198,0.1540638,0.01201582,0.2280093],"study_design_scores_gemma":[0.001866359,0.002918571,0.1020535,0.001417171,0.00442618,0.001352478,0.0007259564,0.2230937,0.001616687,0.6480366,0.01222761,0.0002652195],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5279456,0.07560471,0.2557706,0.1197631,0.00177353,0.000407163,0.00146644,0.00063981,0.01662906],"genre_scores_gemma":[0.9705328,0.004215791,0.01804643,0.005329613,0.0007917642,0.0002021275,0.0001827265,0.00008070975,0.0006181645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09131086,"threshold_uncertainty_score":0.4829037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02673746063725939,"score_gpt":0.2972024756550021,"score_spread":0.2704650150177427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}