{"id":"W2894678218","doi":"10.1021/acs.jnatprod.8b00533","title":"Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a <i>Dictyonella</i> sp. Marine Sponge Collected at the Amazon River Mouth","year":2018,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Agência Nacional do Petróleo, Gás Natural e Biocombustíveis; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Sponge; Alkaloid; Pyrrole; Stereochemistry; Amazon rainforest; Chemistry; Biology; Botany; Organic chemistry; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491921,0.0002824525,0.0003481935,0.00006838548,0.0002341915,0.00002881796,0.0006786347,0.0001778747,0.00007377437],"category_scores_gemma":[0.0008778444,0.0001461332,0.0002205467,0.0006193241,0.0004432498,0.00002163977,0.0007358034,0.000578603,0.000009319407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005463425,"about_ca_system_score_gemma":0.0001856007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000140963,"about_ca_topic_score_gemma":0.0001505865,"domain_scores_codex":[0.9979488,0.0002256026,0.000605582,0.0004039175,0.0004885974,0.0003274761],"domain_scores_gemma":[0.997161,0.0000283094,0.0008730998,0.0006785209,0.001178811,0.00008026803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001855375,0.00008989856,0.002210569,0.00002682501,0.0002089893,0.000007121246,0.0001664033,0.000006758288,0.9652265,0.000003924423,0.02780914,0.00238851],"study_design_scores_gemma":[0.001223718,0.0006742343,0.04619974,0.00006037411,0.0001080121,0.0001880655,0.00002619937,0.00004063283,0.9132555,0.0001099978,0.03788699,0.000226509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896215,0.003790828,0.000001015012,0.004057421,0.001698074,0.000574383,0.00002815509,0.000007702006,0.0002209631],"genre_scores_gemma":[0.9889192,0.0001747434,0.0002347724,0.0003115068,0.002635281,0.000002313701,0.00003770132,0.00003165454,0.00765282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05197097,"threshold_uncertainty_score":0.5959139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004564814790580081,"score_gpt":0.2020812128020034,"score_spread":0.1975163980114233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}