{"id":"W2894678218","doi":"10.1021/acs.jnatprod.8b00533","title":"Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a <i>Dictyonella</i> sp. Marine Sponge Collected at the Amazon River Mouth","year":2018,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Agência Nacional do Petróleo, Gás Natural e Biocombustíveis; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Sponge; Alkaloid; Pyrrole; Stereochemistry; Amazon rainforest; Chemistry; Biology; Botany; Organic chemistry; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005107053,0.000289575,0.0002269235,0.0003274219,0.000153801,0.0001411484,0.00009191515,0.0001240831,0.0007262733],"category_scores_gemma":[0.0000970544,0.0001011633,0.0001613195,0.0002009704,0.0001426812,0.0001057124,0.0001274718,0.0002128433,0.000181227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009286851,"about_ca_system_score_gemma":0.0002119031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262142,"about_ca_topic_score_gemma":0.003270485,"domain_scores_codex":[0.999958,0.000005411085,0.000004317221,0.000009445068,0.00001368123,0.000009081284],"domain_scores_gemma":[0.9999371,0.00001210083,0.00001478244,0.000004418863,0.00001098897,0.00002065203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001830022,0.00001783135,0.000882109,0.00009159628,0.00001058194,0.0001257314,0.00003127581,0.00005293674,0.9949846,0.00001195207,0.00002929685,0.003579069],"study_design_scores_gemma":[0.00009990334,0.002604653,0.09509488,0.00004381879,0.0001153222,0.001759267,0.0001906635,0.000439763,0.8911524,0.00004591539,0.008431115,0.00002229426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942987,0.00291793,0.000466396,0.00004599912,0.00001546415,0.00003255331,0.0005924377,0.00002426002,0.001606304],"genre_scores_gemma":[0.9926032,0.00281571,0.0014286,0.00004976781,0.00001613084,0.00002349881,0.001128252,0.00000889831,0.001926039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262142,"threshold_uncertainty_score":0.002509534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004564814790580081,"score_gpt":0.2020812128020034,"score_spread":0.1975163980114233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}