{"id":"W2894701089","doi":"10.1007/978-3-319-98146-8_5","title":"The Role of mTOR in Osteoclasts","year":2018,"lang":"en","type":"book-chapter","venue":"Stem cell biology and regenerative medicine","topic":"Bone health and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"PI3K/AKT/mTOR pathway; mTORC1; RPTOR; Multinucleate; Osteoclast; Cell biology; Cancer research; Bone resorption; Biology; Mechanistic target of rapamycin; Osteolysis; mTORC2; Protein kinase B; Signal transduction; Chemistry; Medicine; Endocrinology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000262307,0.0002685043,0.0007220727,0.0001197066,0.0001069631,0.00000115525,0.00005806498,0.0004213879,0.0001787499],"category_scores_gemma":[0.00001124783,0.0001299013,0.00004917398,0.00003106013,0.001226684,0.000008280545,0.00003917474,0.0003042293,0.00002579676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000413191,"about_ca_system_score_gemma":0.0001387067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005633544,"about_ca_topic_score_gemma":0.000265197,"domain_scores_codex":[0.9988188,0.00006781857,0.0004559912,0.0003265688,0.0001002594,0.0002305444],"domain_scores_gemma":[0.9990193,0.0002033615,0.0002586759,0.0002594219,0.0001215167,0.0001376851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007368623,0.0004461558,0.04898031,0.001828187,0.00209295,0.0004337388,0.01168908,3.980941e-7,0.037589,0.2912456,0.01753825,0.5807877],"study_design_scores_gemma":[0.006416072,0.008626561,0.001220328,0.001433755,0.0004064334,0.00008260667,0.0006481687,0.00002491414,0.0155755,0.01202849,0.9532241,0.0003130841],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.05141309,0.1692791,0.000003172063,0.002434146,0.0007971348,0.001268605,0.00005559299,0.00001934702,0.7747298],"genre_scores_gemma":[0.3237607,0.009254962,0.00003898169,0.0003085923,0.0005598151,0.00002877753,0.0001482548,0.00003352862,0.6658664],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9356858,"threshold_uncertainty_score":0.5297221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815510535915166,"score_gpt":0.2788850333070347,"score_spread":0.2607299279478831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}