{"id":"W2894749184","doi":"10.1128/aac.01540-18","title":"Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Teicoplanin; Glycopeptide; Microbiology; Antibiotics; Glycopeptide antibiotic; Antibiotic resistance; Antibacterial agent; Biology; Medicine; Bacteria; Vancomycin; Genetics; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097199,0.0002983479,0.0001699571,0.0001571159,0.00007721676,0.0002130376,0.000111322,0.0001956325,0.001302569],"category_scores_gemma":[0.0001675628,0.00009537989,0.0002194406,0.0001194569,0.0001789131,0.00009415936,0.0001949588,0.0004156939,0.0002743963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120167,"about_ca_system_score_gemma":0.0001981755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009563367,"about_ca_topic_score_gemma":0.001143076,"domain_scores_codex":[0.9998482,0.00003179637,0.000009308057,0.00002391908,0.00005361098,0.00003309795],"domain_scores_gemma":[0.9998528,0.00003465424,0.0000376113,0.00002041925,0.00002269046,0.00003184245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002196236,0.000004260957,0.0001097768,0.000004210272,0.000001478729,0.00001603006,0.000003743754,0.00001124896,0.999421,0.00001481411,0.000006575012,0.0003849829],"study_design_scores_gemma":[0.000002111699,0.0001486748,0.003926026,0.000001233112,0.000003680618,0.0001923641,0.00001694714,0.0002012641,0.9949604,0.00001383838,0.0005313348,0.000002057634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949058,0.0003848089,0.002634082,0.00009106271,0.00001381026,0.00001903953,0.0002484226,0.00006038287,0.001642665],"genre_scores_gemma":[0.9952166,0.0001879246,0.001759761,0.00003879849,0.000003107115,0.000008297564,0.0003801992,0.00001977736,0.002385509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302569,"threshold_uncertainty_score":0.004357517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317594926731835,"score_gpt":0.2584845592131356,"score_spread":0.2453086099458173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}