{"id":"W2894830330","doi":"10.2147/dddt.s167382","title":"Synthesis and anticancer activity of dimeric podophyllotoxin derivatives","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; National Key Research and Development Program of China; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Etoposide; Chemistry; Triazole; Cytotoxicity; MTT assay; Click chemistry; Combinatorial chemistry; Stereochemistry; Cell growth; In vitro; Biochemistry; Biology; Chemotherapy; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829667,0.0001640126,0.0001988715,0.00004244591,0.0001157544,0.00001715367,0.00008165024,0.00006796864,0.00001602372],"category_scores_gemma":[0.00002607753,0.0001292074,0.00002554608,0.00006717363,0.0002552551,0.000008683931,0.00004667122,0.00003399893,0.00000124651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004785454,"about_ca_system_score_gemma":0.00006900262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001287662,"about_ca_topic_score_gemma":0.000005694871,"domain_scores_codex":[0.9991965,0.0001208995,0.0001267766,0.000287571,0.00009613625,0.0001720608],"domain_scores_gemma":[0.9996061,0.00007970805,0.00008872079,0.0001263541,0.00004378463,0.00005531178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002672165,0.0000628575,0.003166885,0.000008628414,0.00009918522,5.635255e-7,0.0002954577,6.074455e-8,0.8412226,0.000009198495,0.00006699302,0.1548004],"study_design_scores_gemma":[0.0002232422,0.00009140431,0.04074411,0.00002141996,0.000006027147,0.000003647925,0.00004144256,0.00001202027,0.9530734,0.0000255703,0.005578286,0.0001793603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938849,0.0009385858,0.004733258,0.00006862816,0.00003985333,0.0001630469,0.000004817388,0.000008623222,0.0001582707],"genre_scores_gemma":[0.9914957,0.001962454,0.006284064,0.00006370924,0.00005382202,0.00002543704,0.000002434504,0.00001354386,0.00009881546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.154621,"threshold_uncertainty_score":0.5268927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212688997490328,"score_gpt":0.2391790370952296,"score_spread":0.2170521471203263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}