{"id":"W2894830330","doi":"10.2147/dddt.s167382","title":"Synthesis and anticancer activity of dimeric podophyllotoxin derivatives","year":2018,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; National Key Research and Development Program of China; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Etoposide; Chemistry; Triazole; Cytotoxicity; MTT assay; Click chemistry; Combinatorial chemistry; Stereochemistry; Cell growth; In vitro; Biochemistry; Biology; Chemotherapy; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008656508,0.0002490344,0.0001670491,0.0001418956,0.00009821331,0.0001470531,0.0001693484,0.0001656867,0.000973286],"category_scores_gemma":[0.0001099559,0.00008359076,0.000147637,0.0002078914,0.00008380938,0.0001895659,0.0001393032,0.0003897077,0.0002054168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002051719,"about_ca_system_score_gemma":0.0001417764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000143676,"about_ca_topic_score_gemma":0.0002457942,"domain_scores_codex":[0.9999528,0.000006859625,0.000006119887,0.00001193205,0.00001011208,0.00001221526],"domain_scores_gemma":[0.9999408,0.000004116422,0.00002184157,0.00000807689,0.000009916987,0.00001532833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008618106,0.00007250678,0.0001976695,0.00008399414,0.000008943445,0.00008839702,0.00002456094,0.00043627,0.994709,0.0001605415,0.00008335758,0.004048601],"study_design_scores_gemma":[0.00005118664,0.0009782194,0.00151001,0.00001220273,0.00003629586,0.0003110146,0.00002125957,0.0009516017,0.9890905,0.00007480221,0.006955437,0.000007514243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846502,0.002940709,0.008681169,0.0001313458,0.00004530131,0.00008665473,0.0004047832,0.0000572743,0.003002553],"genre_scores_gemma":[0.990481,0.001790734,0.004708175,0.00005106938,0.000009239804,0.00003727383,0.0005246716,0.00001279869,0.002385097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000973286,"threshold_uncertainty_score":0.003255963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212688997490328,"score_gpt":0.2391790370952296,"score_spread":0.2170521471203263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}