{"id":"W2894884164","doi":"10.3389/fnagi.2018.00296","title":"Alzheimer’s Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health and Demographic Risk Markers","year":2018,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Women and Children’s Health Research Institute","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alberta Innovates; Canada Research Chairs; Canadian Institutes of Health Research; Genome Canada; Alzheimer Society; Consortium canadien en neurodégénérescence associée au vieillissement; Sanofi","keywords":"Cognition; Disease; Medicine; Biomarker; Neuropsychology; Metabolomics; Cognitive decline; Modalities; Dementia; Bioinformatics; Clinical psychology; Psychology; Internal medicine; Psychiatry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009459401,0.0009327742,0.000817373,0.001067507,0.0003403547,0.0007356777,0.0003091169,0.00057796,0.0008646692],"category_scores_gemma":[0.01430005,0.0001581793,0.001062903,0.0005803215,0.0005070214,0.00075599,0.0005942035,0.0009258126,0.0002340849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620254,"about_ca_system_score_gemma":0.0003783204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000831913,"about_ca_topic_score_gemma":0.001074716,"domain_scores_codex":[0.9970023,0.00185985,0.000162664,0.0004418446,0.000359276,0.0001740321],"domain_scores_gemma":[0.9883655,0.009137905,0.0009442109,0.0005876234,0.0005908328,0.0003738852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008054106,0.0004923357,0.9183248,0.0001189208,0.00146433,0.0001091103,0.0001799395,0.003282017,0.01432081,0.00009491032,0.0002946558,0.053264],"study_design_scores_gemma":[0.0001590158,0.00472519,0.9490826,0.00004461276,0.001240797,0.0005233859,0.0001922395,0.03292619,0.009622555,0.0009517286,0.0004836834,0.00004802061],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940457,0.0005729779,0.00448862,0.0001018802,0.00002003804,0.00003308737,0.0001933441,0.00003028792,0.0005140711],"genre_scores_gemma":[0.9972537,0.00006323495,0.002371039,0.00003245575,0.00001641134,0.00001496806,0.0001856427,0.000005293361,0.00005730362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009459401,"threshold_uncertainty_score":0.05002671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03323133838431342,"score_gpt":0.2925105088958222,"score_spread":0.2592791705115088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}