{"id":"W2894958665","doi":"10.1016/j.jcjd.2018.08.006","title":"Mechanisms of Metformin on Colon Cancer Inhibition: Roles of the Gut Microbiome, Butyrate and AMPK","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Metformin; Butyrate; AMPK; Medicine; Microbiome; Colorectal cancer; Cancer research; Cancer; Gut flora; Endocrinology; Internal medicine; Pharmacology; Immunology; Insulin; Biology; Bioinformatics; Biochemistry; Kinase; Protein kinase A","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000614628,0.0007648767,0.0008124951,0.0006028757,0.0003256823,0.001143233,0.000539257,0.0007687415,0.003834999],"category_scores_gemma":[0.0003579671,0.0003268674,0.000964582,0.0003078584,0.0006070348,0.0009785271,0.0007056856,0.001423008,0.0003617314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007050682,"about_ca_system_score_gemma":0.0008571784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081017,"about_ca_topic_score_gemma":0.00264965,"domain_scores_codex":[0.999666,0.00008728408,0.00002127174,0.00004833275,0.00006621606,0.000110972],"domain_scores_gemma":[0.9997991,0.00002836039,0.00005969292,0.00002366036,0.0000292089,0.00006005132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02237687,0.001351716,0.00593178,0.003840514,0.001038372,0.001320242,0.0002896888,0.002050606,0.7613441,0.01763975,0.006104685,0.1767117],"study_design_scores_gemma":[0.004823024,0.01783197,0.151106,0.001438702,0.002417663,0.002499841,0.001265348,0.007817157,0.6478303,0.01815955,0.1445763,0.0002341641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7196628,0.2354424,0.008208725,0.0137587,0.002239618,0.0002655651,0.00158617,0.0003409724,0.01849508],"genre_scores_gemma":[0.9205288,0.06765712,0.002495252,0.001460763,0.0003308003,0.000146129,0.0003804069,0.00003949969,0.006961187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003834999,"threshold_uncertainty_score":0.0128293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006736955769367414,"score_gpt":0.2143404746941605,"score_spread":0.2076035189247931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}