{"id":"W2894963373","doi":"10.3311/ppch.12517","title":"Lipase B from Candida antarctica Immobilized on Epoxy-functionalized Hollow Silica Microspheres: Efficient Biocatalysts for Enantiomer Selective Acylation of Alcohols and Amines","year":2018,"lang":"en","type":"article","venue":"Periodica Polytechnica Chemical Engineering","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Materium Innovations (Canada)","funders":"Emberi Eroforrások Minisztériuma; Budapesti Műszaki és Gazdaságtudományi Egyetem","keywords":"Candida antarctica; Chemistry; Kinetic resolution; Biocatalysis; Enantiomer; Enantiomeric excess; Lipase; Organic chemistry; Selectivity; Acylation; Amine gas treating; Immobilized enzyme; Vinyl acetate; Catalysis; Enantioselective synthesis; Enzyme; Polymer; Copolymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075441,0.0002371458,0.0003077702,0.00007371572,0.00008095703,0.00003079669,0.0001418166,0.0002204781,0.00003089461],"category_scores_gemma":[0.0004942135,0.0002199639,0.0001478282,0.0002383672,0.0002111631,0.000007277923,0.00008402397,0.00008637189,0.000002210978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003727709,"about_ca_system_score_gemma":0.00004041624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005351571,"about_ca_topic_score_gemma":0.000003182315,"domain_scores_codex":[0.9986768,0.00001342179,0.0003674983,0.0005351155,0.0001567961,0.0002504092],"domain_scores_gemma":[0.9991598,0.00008070295,0.0001272953,0.0003558894,0.0001720839,0.0001042141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003083544,0.0001070997,0.0001640848,0.00003272567,0.00009280781,1.958649e-7,0.00006030624,0.0001907817,0.9984555,0.00002648698,0.0002318846,0.0003297649],"study_design_scores_gemma":[0.001119432,0.0002791852,0.001005266,0.00005859507,0.0000740648,0.000004601027,0.00001488207,0.003562962,0.989363,0.000006207172,0.004266031,0.0002457784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902585,0.000700943,0.008273494,0.00005656308,0.00008472415,0.0004005266,0.0001419081,0.00004288452,0.00004049876],"genre_scores_gemma":[0.9957274,0.0000449883,0.003061124,0.00005314739,0.0002214417,0.0001359108,0.0006766705,0.00003922244,0.00004005474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009092513,"threshold_uncertainty_score":0.8969866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006068145973890459,"score_gpt":0.2338403234958242,"score_spread":0.2277721775219338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}