{"id":"W2894963373","doi":"10.3311/ppch.12517","title":"Lipase B from Candida antarctica Immobilized on Epoxy-functionalized Hollow Silica Microspheres: Efficient Biocatalysts for Enantiomer Selective Acylation of Alcohols and Amines","year":2018,"lang":"en","type":"article","venue":"Periodica Polytechnica Chemical Engineering","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Materium Innovations (Canada)","funders":"Emberi Eroforrások Minisztériuma; Budapesti Műszaki és Gazdaságtudományi Egyetem","keywords":"Candida antarctica; Chemistry; Kinetic resolution; Biocatalysis; Enantiomer; Enantiomeric excess; Lipase; Organic chemistry; Selectivity; Acylation; Amine gas treating; Immobilized enzyme; Vinyl acetate; Catalysis; Enantioselective synthesis; Enzyme; Polymer; Copolymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258383,0.000477577,0.0002586613,0.000152018,0.00007288234,0.0002121805,0.0001983006,0.0002830496,0.0003175911],"category_scores_gemma":[0.00009618006,0.0001863009,0.000248192,0.0001314963,0.0001156041,0.0001444775,0.0001999298,0.00021537,0.0002374697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001860555,"about_ca_system_score_gemma":0.0001645011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007985248,"about_ca_topic_score_gemma":0.001200976,"domain_scores_codex":[0.999892,0.00001229163,0.000008414463,0.00002065386,0.00004579401,0.00002087001],"domain_scores_gemma":[0.9999406,0.000007669291,0.00002032793,0.000003834103,0.00001420483,0.00001334433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008920454,0.000001630662,0.00003117101,0.00001046253,0.00000154968,0.000008735287,0.000001579208,0.00001426518,0.9996818,0.000004343292,0.000002591735,0.0002329171],"study_design_scores_gemma":[0.00000362707,0.00005415347,0.001057593,0.000001692713,0.000006688945,0.0000805893,0.000007538189,0.0002479143,0.9980916,0.000004670157,0.0004408524,0.000003113857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942803,0.001628563,0.003298734,0.00004488176,0.00001484475,0.00001919394,0.000125269,0.00003772099,0.0005503934],"genre_scores_gemma":[0.9876931,0.001418258,0.008327682,0.00004284841,0.00001063033,0.00003356234,0.0003581715,0.00001871642,0.00209712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007985248,"threshold_uncertainty_score":0.001587749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006068145973890459,"score_gpt":0.2338403234958242,"score_spread":0.2277721775219338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}