{"id":"W2895006950","doi":"10.1073/pnas.1802166115","title":"Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute; Genentech; University of Texas Southwestern Medical Center; Japan Health Sciences Foundation","keywords":"Atezolizumab; Immune system; PD-L1; Cancer research; Immunotherapy; Lung cancer; Immunity; Biology; Immunology; Medicine; Oncology; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007373785,0.00008158947,0.0001852188,0.0001228065,0.000110175,0.00001272925,0.0001412497,0.00003776846,0.00001376566],"category_scores_gemma":[0.0000711536,0.00003748383,0.00003120958,0.0003537839,0.001320165,0.0001104254,0.00004904002,0.0000490823,1.157432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003827292,"about_ca_system_score_gemma":0.00003325506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004026658,"about_ca_topic_score_gemma":2.768573e-7,"domain_scores_codex":[0.9989461,0.00001583592,0.0002528041,0.0001689953,0.0005245767,0.00009168406],"domain_scores_gemma":[0.999478,0.0001115708,0.0002556602,0.00001266392,0.0001187157,0.0000233305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01356383,0.00004445422,0.002072394,0.00002589027,0.00001587303,5.857816e-9,0.0008846008,7.204106e-7,0.9819453,0.0001838448,0.0001070357,0.001156006],"study_design_scores_gemma":[0.002259186,0.0004765972,0.2783411,0.0003053545,0.00001512411,0.000007355955,0.0002097971,0.0001429173,0.7176809,0.0004242058,0.0001020816,0.00003544068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951622,0.0003086426,8.23869e-7,0.003889729,0.00001140479,0.0003767597,0.00001168591,0.000002989209,0.0002357334],"genre_scores_gemma":[0.9993702,0.00009498402,0.0002300271,0.00009056939,0.00002672778,0.00001173867,1.796438e-7,0.000003119929,0.0001724241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2762687,"threshold_uncertainty_score":0.4864204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625751836405695,"score_gpt":0.2818716819560145,"score_spread":0.2656141635919576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}