{"id":"W2895149561","doi":"10.1016/j.taap.2018.10.010","title":"Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways","year":2018,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Korea Health Industry Development Institute","keywords":"Endoplasmic reticulum; Protein kinase B; Chemistry; Cell biology; Protein kinase A; Reactive oxygen species; Signal transduction; PI3K/AKT/mTOR pathway; Kinase; Mitogen-activated protein kinase; Signal pathway; Biochemistry; Cancer research; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001283756,0.0003528733,0.0003277663,0.00005716151,0.0004149501,0.00002865611,0.0001126783,0.0003377649,0.0001241776],"category_scores_gemma":[0.00002608418,0.0003377195,0.00003144916,0.0001042462,0.0008367028,0.00002330863,0.0002039018,0.0002691887,0.000001982871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003426624,"about_ca_system_score_gemma":0.0001079902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000896567,"about_ca_topic_score_gemma":0.00006343379,"domain_scores_codex":[0.998008,0.0001892444,0.0002542294,0.0009868412,0.00009592321,0.0004657997],"domain_scores_gemma":[0.9992327,0.00004280007,0.0001999623,0.0001489646,0.0001506797,0.0002248716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001623577,0.0003016217,0.002424469,0.00010525,0.0001699107,0.000009426023,0.0003104829,0.000004086601,0.9926591,0.0000597222,0.001815389,0.0005169608],"study_design_scores_gemma":[0.001639929,0.000555885,0.003831527,0.00001974448,0.0001381405,0.00009437721,0.0002922849,0.0000321553,0.9924965,0.0001064876,0.000431427,0.0003615318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960977,0.001565298,0.00005461502,0.0003099718,0.0002274697,0.000878834,0.0002861826,0.00003614245,0.0005437371],"genre_scores_gemma":[0.9974132,0.0008387873,0.00007697133,0.0003058887,0.0005722925,0.000462288,0.00009799626,0.00003585844,0.0001967019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407059,"threshold_uncertainty_score":0.9999075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006830953253923045,"score_gpt":0.2260783192833919,"score_spread":0.2192473660294689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}