{"id":"W2895149561","doi":"10.1016/j.taap.2018.10.010","title":"Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways","year":2018,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Korea Health Industry Development Institute","keywords":"Endoplasmic reticulum; Protein kinase B; Chemistry; Cell biology; Protein kinase A; Reactive oxygen species; Signal transduction; PI3K/AKT/mTOR pathway; Kinase; Mitogen-activated protein kinase; Signal pathway; Biochemistry; Cancer research; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006074494,0.0002138364,0.0001503374,0.0002083339,0.0001457283,0.0002063506,0.0001481814,0.000157742,0.001263656],"category_scores_gemma":[0.0000912892,0.00008165236,0.0001524829,0.0001739927,0.0001606297,0.0001351969,0.0001174276,0.0003465769,0.0002600937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787662,"about_ca_system_score_gemma":0.0002587627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466718,"about_ca_topic_score_gemma":0.003214255,"domain_scores_codex":[0.9999162,0.00001716787,0.000005191908,0.00001204103,0.00002307351,0.00002618915],"domain_scores_gemma":[0.9999188,0.00001857215,0.00001759728,0.00001369764,0.0000131013,0.00001818703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002254586,0.0000192704,0.0001535964,0.0000211162,0.00000603255,0.00003141591,0.000005165822,0.00003988255,0.9985822,0.00006626594,0.00003492153,0.0008146502],"study_design_scores_gemma":[0.00001948613,0.0002180543,0.003746018,0.000002108615,0.0000151506,0.0001433276,0.00001779764,0.000227055,0.9940134,0.00003271041,0.001561991,0.000003004747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955913,0.001101937,0.001081956,0.000134619,0.00002284038,0.0000162304,0.0003653727,0.00006120949,0.001624623],"genre_scores_gemma":[0.9966303,0.0006988911,0.0004839231,0.00002516561,0.000005862582,0.000007792048,0.0002888221,0.000007654552,0.001851691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466718,"threshold_uncertainty_score":0.00422734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006830953253923045,"score_gpt":0.2260783192833919,"score_spread":0.2192473660294689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}