{"id":"W2895262232","doi":"10.1038/s41598-018-33243-y","title":"Naturally Occurring Variations Modulate the Activity of the HPV33 Early Promoter and its Affinity for the E2 Transcription Factor","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Government of Canada; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Transcription factor; Transcription (linguistics); Biology; Computational biology; Bioinformatics; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162084,0.0001466515,0.0001778423,0.0001789126,0.00009927827,0.0002570229,0.0001327507,0.00020865,0.001226777],"category_scores_gemma":[0.0004073783,0.0001139218,0.000163389,0.000134596,0.0001973833,0.0001096571,0.0001716141,0.0002884367,0.0001687792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085494,"about_ca_system_score_gemma":0.0001227901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005935356,"about_ca_topic_score_gemma":0.0007239021,"domain_scores_codex":[0.9997899,0.0000646242,0.00001485267,0.00004716542,0.00003948609,0.00004395873],"domain_scores_gemma":[0.9998115,0.00007118884,0.00004552689,0.00002390767,0.00002162246,0.00002632995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001866062,0.00005294106,0.004204864,0.00001983307,0.00001246061,0.00004400889,0.00004582991,0.00005089254,0.9939658,0.0000747041,0.00001949104,0.001322616],"study_design_scores_gemma":[0.00003048262,0.0007835703,0.1550425,0.00001384862,0.00008272352,0.001302877,0.0003159224,0.001949576,0.8378435,0.0002736433,0.002337634,0.000023734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987355,0.0003226405,0.0005895748,0.00001824468,0.00000555516,0.000005481202,0.00007227074,0.000008846089,0.0002417842],"genre_scores_gemma":[0.9992926,0.0001257527,0.0003110153,0.00001293963,0.000002290088,0.000004353024,0.00007331961,0.000007280529,0.0001704486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226777,"threshold_uncertainty_score":0.004104018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05514392090471575,"score_gpt":0.3311686372565447,"score_spread":0.276024716351829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}