{"id":"W2895362009","doi":"10.1111/bju.14576","title":"DNA repair defects in prostate cancer: impact for screening, prognostication and treatment","year":2018,"lang":"en","type":"review","venue":"British Journal of Urology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"Medicine; Prostate cancer; DNA repair; Poly ADP ribose polymerase; DNA mismatch repair; Cancer; PARP inhibitor; Cancer research; Homologous recombination; BRCA2 Protein; Germline; DNA damage; Germline mutation; DNA Damage Repair; Gene; Bioinformatics; Internal medicine; Genetics; Polymerase; Mutation; DNA; Biology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000871487,0.0004627427,0.001306997,0.00217903,0.0002069116,0.0008770943,0.0007469065,0.0008823011,0.003445593],"category_scores_gemma":[0.001860148,0.0002158564,0.0005859142,0.001967959,0.0004770913,0.0008089743,0.0004739485,0.001466012,0.001131437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006831491,"about_ca_system_score_gemma":0.00136959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218772,"about_ca_topic_score_gemma":0.003413778,"domain_scores_codex":[0.9996297,0.00008536718,0.0000652391,0.00005337971,0.0001428621,0.00002347803],"domain_scores_gemma":[0.9989711,0.0006263673,0.0001172852,0.00002313417,0.0002181957,0.00004396405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005747036,0.00003277537,0.0006058946,0.01837235,0.0001337365,0.0001972299,0.00005111095,0.0003003734,0.0004731525,0.002173914,0.02246021,0.9551417],"study_design_scores_gemma":[0.00001972806,0.0001221944,0.003850747,0.01650579,0.0003108397,0.003424961,0.000127063,0.0001381305,0.0003127329,0.003156244,0.9719989,0.00003265508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006184694,0.9991587,0.00003886079,0.0003470972,0.00007437426,0.000001430538,0.00001511983,0.000002339369,0.0003001851],"genre_scores_gemma":[0.0006133628,0.9988869,0.00008506912,0.0001383385,0.0001012504,0.000001933053,0.00002203212,7.938613e-7,0.0001503777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003445593,"threshold_uncertainty_score":0.01152664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05511345156333994,"score_gpt":0.3934676395728771,"score_spread":0.3383541880095371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}