{"id":"W2895374294","doi":"10.1111/cge.13455","title":"Complex effects of laminopathy mutations on nuclear structure and function","year":2018,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Genome Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Function (biology); Genetics; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005064066,0.0007748669,0.001173156,0.002225565,0.0002884554,0.0008531591,0.0007692581,0.0009596225,0.00331923],"category_scores_gemma":[0.0008684509,0.0002323394,0.0003334189,0.001646919,0.000518,0.001074004,0.0007797467,0.001689358,0.002055478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008819381,"about_ca_system_score_gemma":0.0009602522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001119764,"about_ca_topic_score_gemma":0.00198995,"domain_scores_codex":[0.9997957,0.00002842133,0.00004085862,0.00004410604,0.00007342113,0.00001747451],"domain_scores_gemma":[0.9996971,0.0001409536,0.00003764394,0.00001137075,0.00008068999,0.00003231235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005024192,0.00002483589,0.0002080642,0.008402225,0.00006371413,0.0004597098,0.00005749344,0.0002486517,0.001085469,0.004124375,0.04297274,0.9423023],"study_design_scores_gemma":[0.000008870545,0.00002520396,0.000592645,0.002159947,0.00005355115,0.002899955,0.00003197106,0.00003525948,0.0002884872,0.001478077,0.9924148,0.00001140927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009787358,0.9978181,0.0001353043,0.0003656364,0.0002196987,0.000003201997,0.00002198371,0.00001084243,0.001327398],"genre_scores_gemma":[0.0006484305,0.9977768,0.0001615393,0.0002724604,0.0002236111,0.000004862021,0.00004112737,0.000002824356,0.0008683641],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00331923,"threshold_uncertainty_score":0.01110393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378788201504113,"score_gpt":0.3530785624568779,"score_spread":0.3092906804418368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}