{"id":"W2895374294","doi":"10.1111/cge.13455","title":"Complex effects of laminopathy mutations on nuclear structure and function","year":2018,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Genome Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Function (biology); Genetics; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009482372,0.0002577337,0.0006429197,0.00004902959,0.00006393247,0.0000158493,0.0001415916,0.0006900349,0.00002940332],"category_scores_gemma":[0.0001836112,0.0002111857,0.0002701978,0.00007952167,0.0002729829,0.000001048576,0.0001109009,0.0002354606,0.00002018553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006076778,"about_ca_system_score_gemma":0.00005189352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.574663e-7,"about_ca_topic_score_gemma":0.00000222178,"domain_scores_codex":[0.9985691,0.0001850571,0.0005374389,0.0004614904,0.0001070794,0.0001398092],"domain_scores_gemma":[0.9989483,0.0001007019,0.0003274377,0.0004558418,0.00007929998,0.00008841262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005408746,0.00005603395,0.00003011093,0.002930483,0.0002386217,0.000001616455,0.000009111071,0.00000104503,0.0003839703,0.00008233655,0.004583275,0.9916293],"study_design_scores_gemma":[0.0002799289,0.001983591,0.0008870388,0.0004571492,0.0006732456,0.00001188654,0.000003066659,0.000008154274,0.00007385688,0.00009147129,0.9953272,0.000203385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02140676,0.9762655,0.00006073699,0.000006545436,0.001396884,0.0005069699,0.00009130432,0.00001433647,0.0002509563],"genre_scores_gemma":[0.004109267,0.9932264,0.0007114242,0.0001762079,0.00123766,0.00000384368,0.0003514707,0.00006439081,0.0001193543],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9914259,"threshold_uncertainty_score":0.8611903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04378788201504113,"score_gpt":0.3530785624568779,"score_spread":0.3092906804418368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}