{"id":"W2895501562","doi":"10.1128/aac.01231-18","title":"Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Università degli Studi di Pavia; Government of Canada; Cystic Fibrosis Canada; University of Manitoba; Research Manitoba; Cystic Fibrosis Foundation","keywords":"FtsZ; Gene; Biology; Cell division; Division (mathematics); Genetics; Broad spectrum; Bacterial protein; Cell; Cell biology; Computational biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172284,0.0003537836,0.0003418727,0.0002502831,0.000164802,0.0003229195,0.0002971593,0.0002689068,0.001293677],"category_scores_gemma":[0.0001517003,0.0001579442,0.0002253865,0.0001500193,0.0002260972,0.0001374529,0.0002335385,0.0005587027,0.00047167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000450456,"about_ca_system_score_gemma":0.0002617692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166729,"about_ca_topic_score_gemma":0.002855262,"domain_scores_codex":[0.9998241,0.00001458364,0.00001574855,0.00003778112,0.0000715657,0.00003633271],"domain_scores_gemma":[0.9998678,0.0000297783,0.0000342376,0.00001371257,0.0000138153,0.00004068425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002543437,0.000008858559,0.0000863205,0.000005572736,0.000002617561,0.00002046222,0.000002217893,0.00004074809,0.9993178,0.00006897978,0.00002878748,0.0003921588],"study_design_scores_gemma":[0.000008327031,0.000127413,0.006010003,0.000002847985,0.00001410714,0.0001889595,0.00002052804,0.002461181,0.9900075,0.0000580616,0.001095619,0.000005261062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932975,0.0005559735,0.003790591,0.0001242534,0.00002912746,0.00001283166,0.0006750017,0.0001313003,0.001383395],"genre_scores_gemma":[0.995675,0.0003076238,0.001357933,0.00005644969,0.000003542232,0.00001531923,0.000632269,0.00005672643,0.001895048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293677,"threshold_uncertainty_score":0.004327834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004777734577505929,"score_gpt":0.2248226935383587,"score_spread":0.2200449589608527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}