{"id":"W2895507830","doi":"10.1021/acs.jmedchem.8b01258","title":"Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"Akademie Věd České Republiky; Technologická Agentura České Republiky; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Gilead Sciences","keywords":"Chemistry; Stereochemistry; Combinatorial chemistry; Cytotoxic T cell; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131156,0.0002200025,0.0002139094,0.0003915715,0.0001217755,0.0002228324,0.0001484238,0.0001826492,0.0007177134],"category_scores_gemma":[0.0001752284,0.00007858119,0.0001342164,0.0002614255,0.0001029406,0.0001218965,0.00009919584,0.0001578727,0.000182812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550718,"about_ca_system_score_gemma":0.0001607997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003356819,"about_ca_topic_score_gemma":0.0006980088,"domain_scores_codex":[0.9998945,0.00001948618,0.00001042139,0.00002521416,0.00003489563,0.0000154971],"domain_scores_gemma":[0.9999105,0.00001349849,0.00002001026,0.00001292462,0.00002464706,0.00001841754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009821745,0.00003956934,0.000498738,0.00006746699,0.000009705692,0.00006445411,0.00001828226,0.0008878455,0.9890504,0.0001410147,0.00003542639,0.009088919],"study_design_scores_gemma":[0.00001021913,0.0008791497,0.002625024,0.000007761606,0.00003643783,0.0002941813,0.00002117903,0.0007444252,0.9922482,0.00005145717,0.003073838,0.000008195294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863214,0.005610076,0.002564412,0.00004253973,0.0000173595,0.00007309159,0.0007388857,0.00004089356,0.004591341],"genre_scores_gemma":[0.9871748,0.002769509,0.006748968,0.00004890151,0.00001252462,0.00004429222,0.001434849,0.00001245758,0.001753625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007177134,"threshold_uncertainty_score":0.002400935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009994041818971858,"score_gpt":0.2532842068645368,"score_spread":0.2432901650455649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}