{"id":"W2895512177","doi":"10.1126/scitranslmed.aar3959","title":"Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease","year":2018,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research; Ionis Pharmaceuticals; Huntington Society of Canada","keywords":"Huntingtin; Huntington's disease; Huntingtin Protein; Gain of function; Cognition; Mutant; Disease; Neuroscience; Trinucleotide repeat expansion; Function (biology); Biology; Cell biology; Medicine; Genetics; Allele; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004807794,0.0001418368,0.0001592176,0.0004372766,0.0002296238,0.00001399556,0.0002873652,0.00002003815,0.0001421969],"category_scores_gemma":[0.002814288,0.0001168322,0.00003270732,0.0009384104,0.00280683,0.0003608687,0.00003624288,0.0001012351,0.00001123025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001591907,"about_ca_system_score_gemma":0.0003596098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002120138,"about_ca_topic_score_gemma":0.00002465905,"domain_scores_codex":[0.9975129,0.0001014594,0.0003577152,0.0006058485,0.001124989,0.0002970516],"domain_scores_gemma":[0.9989113,0.0002832395,0.0001275957,0.0001895384,0.0002949078,0.0001934005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002994388,0.00009450464,0.01252615,0.00001554854,6.583093e-7,3.907872e-7,0.000702613,0.001455373,0.9819404,0.002286151,0.00002087162,0.0006578976],"study_design_scores_gemma":[0.0008664802,0.0001547936,0.08867828,0.0001406838,0.00001852191,1.983096e-7,0.00008672933,0.03750245,0.8688991,0.003533446,0.000007290263,0.0001119918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935172,0.00002298695,0.003674445,0.0009390409,0.0002175021,0.000295226,0.00005642926,0.00003064191,0.001246487],"genre_scores_gemma":[0.9988914,0.000006361643,0.0002795367,0.0004980332,0.000131428,0.0000202506,0.000005813477,0.00001156733,0.0001556229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1130413,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05379839418543318,"score_gpt":0.3178338071769342,"score_spread":0.264035412991501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}