{"id":"W2895548902","doi":"10.1161/circ.132.suppl_3.17627","title":"Abstract 17627: Is the Post-menopausal Rise in PCSK9 Levels Due to Loss of the Estrogen Responsive Anti-atherogenic Protein, Heat Shock Protein 27? Insights Into a Potential New PCSK9 Lowering Therapy","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"","keywords":"Medicine; Internal medicine; PCSK9; Endocrinology; LDL receptor; Apolipoprotein B; Western blot; Cholesterol; Heat shock protein; Lipoprotein; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805647,0.0004253251,0.0005582505,0.0002077422,0.0001393833,0.0003621194,0.0002636414,0.0005416797,0.008743669],"category_scores_gemma":[0.0001941293,0.0001382982,0.0003466011,0.0001906957,0.0005105155,0.0002063392,0.0001761917,0.0007064224,0.001795731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003535606,"about_ca_system_score_gemma":0.0003617052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004088661,"about_ca_topic_score_gemma":0.0004041776,"domain_scores_codex":[0.9999422,0.000007613569,0.000006397489,0.00001362614,0.00001756861,0.00001262045],"domain_scores_gemma":[0.9999113,0.0000128312,0.00003465584,0.000006636328,0.00001431096,0.00002022277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01304477,0.0006274973,0.01507306,0.002927433,0.000290581,0.004238961,0.0001460466,0.0002146431,0.8316813,0.001301561,0.01067783,0.1197763],"study_design_scores_gemma":[0.001356168,0.01196776,0.3024453,0.0005724682,0.0008955618,0.01690642,0.0006618631,0.001152843,0.5506811,0.002729846,0.1105411,0.00008958463],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8650125,0.1020858,0.004894762,0.01069154,0.001126154,0.0002348971,0.003577778,0.000377248,0.01199928],"genre_scores_gemma":[0.917329,0.04488422,0.001857267,0.002532994,0.001101258,0.0001340436,0.003228346,0.00007745508,0.02885524],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.008743669,"threshold_uncertainty_score":0.0292505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03529878988272813,"score_gpt":0.2781060367312769,"score_spread":0.2428072468485487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}