{"id":"W2895590704","doi":"10.1093/ibd/izy304","title":"Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1","year":2018,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University; University of British Columbia","funders":"Takeda Pharmaceuticals International","keywords":"Vedolizumab; Calprotectin; Internal medicine; Ulcerative colitis; Medicine; Gastroenterology; Placebo; Biomarker; Surrogate endpoint; Population; Area under the curve; Faecal calprotectin; Inflammatory bowel disease; Disease; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005612367,0.0006955208,0.002582676,0.0003687861,0.0002462537,0.0007942402,0.000652221,0.0005970827,0.001552092],"category_scores_gemma":[0.004919989,0.0002274724,0.002401806,0.0002826136,0.0004973671,0.000616899,0.0004899477,0.001452052,0.0002335806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005805768,"about_ca_system_score_gemma":0.0006866081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232504,"about_ca_topic_score_gemma":0.0004890512,"domain_scores_codex":[0.9973745,0.001497697,0.0001497835,0.0003898504,0.0002758265,0.0003122956],"domain_scores_gemma":[0.9945599,0.003126312,0.0008505699,0.0006459198,0.000287955,0.0005292358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8860551,0.004212772,0.06931847,0.000297021,0.005532589,0.0001516342,0.0001817746,0.001378329,0.01077625,0.00006204767,0.0007342806,0.02129966],"study_design_scores_gemma":[0.02072354,0.3433441,0.6094018,0.00003912277,0.00638709,0.0002075841,0.0001821882,0.009826334,0.008152969,0.0001582908,0.001509086,0.00006783711],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989632,0.0002916597,0.0002273229,0.00003871807,0.00002869264,0.00007827248,0.0001595626,0.00001418277,0.000198264],"genre_scores_gemma":[0.9988769,0.00005769368,0.0002486343,0.00004228078,0.00002854026,0.0001033438,0.0003239847,0.000007819465,0.0003108142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005612367,"threshold_uncertainty_score":0.02968144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003941316433623,"score_gpt":0.2577933107713151,"score_spread":0.2477538976069789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}