{"id":"W2895601944","doi":"10.1074/jbc.ra118.005134","title":"Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Seaweed-derived Bioactive Compounds","field":"Agricultural and Biological Sciences","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Fucoidan; Glycoside hydrolase; Biochemistry; Enzyme; Brown algae; Chemistry; Sulfation; Hydrolase; Polysaccharide; Stereochemistry; Biology; Algae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839886,0.0003966085,0.0006003539,0.00001752074,0.0003112438,0.0001833535,0.0006110329,0.0003105424,0.0008694052],"category_scores_gemma":[0.0006350779,0.0001585246,0.0002183688,0.0001961461,0.0004198894,0.0002040002,0.000310233,0.0003813652,0.00001799754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008180462,"about_ca_system_score_gemma":0.00002257304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712806,"about_ca_topic_score_gemma":0.00005947481,"domain_scores_codex":[0.9978977,0.0001217604,0.0006103971,0.0005302631,0.0003822692,0.0004576257],"domain_scores_gemma":[0.9975976,0.001161173,0.0003857838,0.0001211377,0.0002351511,0.000499181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005020148,0.00006652385,0.006740143,0.000003755823,0.00007410739,0.00007641764,0.00004459401,0.000001395137,0.9880913,0.00001012637,0.0002731953,0.004116427],"study_design_scores_gemma":[0.0005022264,0.001280809,0.1590073,0.0001018841,0.00007153955,0.0001034972,0.000646921,0.0001147932,0.827818,0.006112596,0.003752849,0.0004875892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971123,0.0007955087,0.00004301868,0.0006737647,0.0002355574,0.0001123368,0.0007068645,0.00005141675,0.0002691711],"genre_scores_gemma":[0.9958022,0.0001039629,0.0007501758,0.0009932797,0.002198692,0.000005439839,0.0001086092,0.000003560126,0.00003412103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1602733,"threshold_uncertainty_score":0.9519377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564119347532104,"score_gpt":0.2335441146136579,"score_spread":0.2079029211383368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}