{"id":"W2895642842","doi":"10.1136/annrheumdis-2018-eular.2727","title":"SAT0575 Safety and efficacy of lutikizumab (ABT-981), an anti–interleukin-1 alpha/beta dual variable domain (DVD) immunoglobulin, in subjects with knee osteoarthritis: results from the randomised, double-blind, placebo-controlled, parallel-group phase 2 trial","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; WOMAC; Osteoarthritis; Synovitis; Placebo; Visual analogue scale; Knee pain; Clinical endpoint; Internal medicine; Gastroenterology; Urology; Randomized controlled trial; Arthritis; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001333971,0.001251733,0.002039302,0.0004411051,0.0003276718,0.001048249,0.0007292701,0.001455477,0.004260708],"category_scores_gemma":[0.001354653,0.0005652005,0.001920194,0.0003651504,0.000995093,0.001033539,0.0002446175,0.002243363,0.00098443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005276203,"about_ca_system_score_gemma":0.000645342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000748515,"about_ca_topic_score_gemma":0.001226922,"domain_scores_codex":[0.99951,0.0002331553,0.00004539742,0.00007133072,0.0000562302,0.00008377573],"domain_scores_gemma":[0.999477,0.0001815814,0.0001213682,0.00003528694,0.00003351057,0.0001512584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9628829,0.003596389,0.0007914655,0.0006742364,0.001182301,0.0000476943,0.00004363584,0.0003271543,0.005439559,0.00008373556,0.0005913661,0.02433962],"study_design_scores_gemma":[0.8816549,0.1080393,0.006776732,0.00005276982,0.001141838,0.00007319183,0.00003710594,0.0004991257,0.0009702324,0.0001296648,0.000597563,0.00002763639],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889262,0.007368004,0.0002813628,0.0003409096,0.0002903989,0.0004224178,0.0006511871,0.00009407787,0.00162559],"genre_scores_gemma":[0.9937878,0.002590945,0.0003519623,0.0005631028,0.0002716332,0.0003020599,0.0009411882,0.00001245879,0.001178763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004260708,"threshold_uncertainty_score":0.0142535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557528883957882,"score_gpt":0.2934223971733086,"score_spread":0.2678471083337298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}