{"id":"W2895709672","doi":"10.3390/ht7040030","title":"Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies","year":2018,"lang":"en","type":"article","venue":"High-Throughput","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"CTCF; Enhancer; Insulator (electricity); Biology; Regulator; Genetics; Genome; Gene; Transcription factor; Computational biology; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551351,0.0002298966,0.0004620529,0.0001329106,0.00008239113,0.00003356085,0.0002743485,0.0001982728,0.00002915233],"category_scores_gemma":[0.00005794931,0.0002233541,0.0000972075,0.0003306687,0.0001702454,0.00001602105,0.0002692656,0.00008954644,0.000003231819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005021369,"about_ca_system_score_gemma":0.00009603638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001996241,"about_ca_topic_score_gemma":0.004984313,"domain_scores_codex":[0.9984719,0.00008544857,0.0004207119,0.0006141806,0.0001260774,0.0002816893],"domain_scores_gemma":[0.9989312,0.00001654172,0.0001919774,0.0005602454,0.0002001118,0.00009991656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008407395,0.0002048465,0.042604,0.00004134165,0.001372746,0.00001067386,0.000842442,0.00279284,0.949909,0.001237693,0.0002202935,0.00068004],"study_design_scores_gemma":[0.003342176,0.001208175,0.5866457,0.00007632356,0.001285193,0.000005583549,0.001320109,0.01659362,0.3819245,0.00334186,0.002943499,0.001313263],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921227,0.006657637,0.0003146043,0.0001489062,0.0001672634,0.0001680938,0.0003752964,0.00001064426,0.00003487489],"genre_scores_gemma":[0.9948936,0.002653122,0.001552862,0.0001498114,0.0001799372,0.00003001822,0.0004787522,0.00002922986,0.00003270595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5679845,"threshold_uncertainty_score":0.9108115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578989141967918,"score_gpt":0.2869994229502457,"score_spread":0.2712095315305665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}