{"id":"W2895714694","doi":"10.1016/j.biopsych.2018.08.022","title":"Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis","year":2018,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Economic and Social Research Council; Cardiff University; Medical Research Council; Medical Research Council Canada; Johns Hopkins University; Seventh Framework Programme; Svenska Forskningsrådet Formas; Sylvan C. Herman Foundation; Wellcome Trust; National Institute of Mental Health; Vetenskapsrådet; Stanley Medical Research Institute","keywords":"Sodium channel; Pathogenesis; Schizophrenia (object-oriented programming); Neuroscience; Biology; Genetics; Medicine; Sodium; Chemistry; Psychiatry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172812,0.00015738,0.0002011335,0.00007078202,0.00005378194,0.00001183862,0.00009003396,0.000236856,0.00004539737],"category_scores_gemma":[0.00006639866,0.000122238,0.00005082473,0.0001329027,0.0002649691,0.000007503374,0.00007713388,0.00007785796,0.000002566307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001254097,"about_ca_system_score_gemma":0.00005645015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001496073,"about_ca_topic_score_gemma":0.0002192391,"domain_scores_codex":[0.9990057,0.0001045534,0.0002573098,0.0003561389,0.00005969167,0.0002165991],"domain_scores_gemma":[0.9996128,0.00002299444,0.0001039546,0.0001531935,0.00005316814,0.00005388631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008863048,0.00007083407,0.1182482,0.00001974969,0.00001283443,5.515632e-7,0.00003284415,0.00001201585,0.8794083,0.0001617056,0.0001184713,0.001028166],"study_design_scores_gemma":[0.0009431976,0.0005938544,0.7722293,0.00002404667,0.000004622726,0.000008451071,0.0001129122,0.0001789152,0.2242055,0.0007056477,0.0007928568,0.0002007413],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985107,0.0005523326,0.0001591221,0.0001423051,0.0003207984,0.0001514314,0.00004911661,0.00001528404,0.0000988822],"genre_scores_gemma":[0.9990299,0.000103169,0.0003435837,0.0001403068,0.0002042705,0.00001215764,0.0001017344,0.000008299256,0.00005660972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6552028,"threshold_uncertainty_score":0.498472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594177382759763,"score_gpt":0.2540245712407625,"score_spread":0.2280827974131649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}