{"id":"W2895782917","doi":"10.1016/j.breast.2018.10.001","title":"Targeting CDK4/6 pathways and beyond in breast cancer","year":2018,"lang":"en","type":"review","venue":"The Breast","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Palbociclib; Oncology; Metastatic breast cancer; Internal medicine; Fulvestrant; Breast cancer; Neutropenia; Cancer; Clinical trial; Disease; Adjuvant; Adjuvant therapy; Toxicity; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004415819,0.0005958364,0.001666329,0.0001834387,0.0001363852,0.0000360803,0.0003093944,0.0002538797,0.0003703432],"category_scores_gemma":[0.00001790253,0.000357539,0.0002236606,0.0004664336,0.0004249668,0.0001103089,0.0002044778,0.0007001192,0.00008757163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528375,"about_ca_system_score_gemma":0.0004536115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001898654,"about_ca_topic_score_gemma":0.00003129401,"domain_scores_codex":[0.9977313,0.0001569278,0.0006077922,0.0006075056,0.000313997,0.0005825327],"domain_scores_gemma":[0.9986067,0.0001380756,0.0003584613,0.0006155657,0.0001108562,0.0001703254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001018355,0.00004839004,0.0001372756,0.004925418,0.0001815658,0.00003667861,0.0003093192,4.923525e-7,0.000006941978,0.00009897383,0.0004012427,0.9937519],"study_design_scores_gemma":[0.0009642935,0.00004102215,0.001097934,0.02270943,0.000815168,0.009810731,0.0001933394,0.00001401856,8.500832e-7,0.0002670496,0.9635401,0.0005460102],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007256066,0.9961859,0.00001429711,0.0009697903,0.0002851361,0.0009670203,0.000671094,0.00008324252,0.0007509841],"genre_scores_gemma":[0.0002568453,0.9965779,0.0001690381,0.0003986687,0.001735182,0.000284409,0.00007643046,0.0001497027,0.0003518387],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932058,"threshold_uncertainty_score":0.9998876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0316510750787628,"score_gpt":0.3233811829162637,"score_spread":0.2917301078375009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}