{"id":"W2895798257","doi":"10.1016/j.bcp.2018.10.020","title":"Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy","year":2018,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Marsden Fund; Victoria University of Wellington","keywords":"Prodrug; Nitroreductase; Enzyme; Biochemistry; Activator (genetics); Chemistry; Pharmacology; Escherichia coli; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003487129,0.0003112671,0.0002266422,0.0001535193,0.0001104766,0.0002504639,0.000222032,0.0002995287,0.000883929],"category_scores_gemma":[0.0003287814,0.0001007532,0.000142129,0.0001658707,0.0001394826,0.0003163482,0.0001248903,0.0003802501,0.0001926635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171536,"about_ca_system_score_gemma":0.0002268012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532441,"about_ca_topic_score_gemma":0.0009794001,"domain_scores_codex":[0.9998323,0.00003444703,0.0000177737,0.00002693831,0.00004774499,0.00004070757],"domain_scores_gemma":[0.9998559,0.00004846056,0.00003370359,0.00001327036,0.00002640535,0.0000221955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155102,0.00008728714,0.0001575911,0.00002125563,0.000003494803,0.00001986902,0.00001496663,0.0004180625,0.9976743,0.0001075144,0.00001610129,0.001324575],"study_design_scores_gemma":[0.000007792104,0.001080387,0.0004693073,0.00000226322,0.000008510129,0.00004269528,0.00001133931,0.001175003,0.996837,0.00002167671,0.0003412399,0.000002677108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963281,0.000230536,0.002566732,0.00001932074,0.000007037877,0.00004198393,0.0001287425,0.00002508663,0.0006525833],"genre_scores_gemma":[0.9938849,0.0004619204,0.003482453,0.00001290073,0.000002191271,0.00003115237,0.0004286612,0.00002350928,0.001672374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000883929,"threshold_uncertainty_score":0.002957046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07715803561047156,"score_gpt":0.4177914879679701,"score_spread":0.3406334523574985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}