{"id":"W2895804499","doi":"10.1161/circgen.118.002327","title":"Confirmation of Causal rs9349379- <i>PHACTR1</i> Expression Quantitative Trait Locus in Human-Induced Pluripotent Stem Cell Endothelial Cells","year":2018,"lang":"en","type":"letter","venue":"Circulation Genomic and Precision Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Induced pluripotent stem cell; Biology; Locus (genetics); Human Induced Pluripotent Stem Cells; Stem cell; Expression quantitative trait loci; Trait; Genetics; Quantitative trait locus; Cell biology; Embryonic stem cell; Gene; Computer science; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001768539,0.0006113033,0.000525433,0.001023353,0.0006459025,0.0008413338,0.0006661831,0.001836092,0.02036496],"category_scores_gemma":[0.004187892,0.000203734,0.000960853,0.0008695381,0.0005874825,0.0002595103,0.0003615306,0.001645165,0.003547811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000553398,"about_ca_system_score_gemma":0.0004853156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903984,"about_ca_topic_score_gemma":0.002322655,"domain_scores_codex":[0.9983842,0.0002593021,0.0001976267,0.0003736845,0.0006329013,0.0001523373],"domain_scores_gemma":[0.9978071,0.0009142557,0.000339751,0.0004285533,0.0003315335,0.0001788475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003311671,0.0007768034,0.1640651,0.001136722,0.001024918,0.07453192,0.001429622,0.002528711,0.4784532,0.01914767,0.07890012,0.1746935],"study_design_scores_gemma":[0.001489867,0.001636072,0.2552847,0.001177083,0.001138622,0.1210376,0.0007963271,0.01087841,0.4082504,0.01378421,0.18426,0.0002667018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7966573,0.004102984,0.08736683,0.01147328,0.004492716,0.001170747,0.05134369,0.003217988,0.0401744],"genre_scores_gemma":[0.9529974,0.001304073,0.01517667,0.003144243,0.0005377971,0.0004038718,0.01602427,0.0005647999,0.009846975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02036496,"threshold_uncertainty_score":0.06812763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02633735647304427,"score_gpt":0.2734473169570781,"score_spread":0.2471099604840338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}