{"id":"W2895804499","doi":"10.1161/circgen.118.002327","title":"Confirmation of Causal rs9349379- <i>PHACTR1</i> Expression Quantitative Trait Locus in Human-Induced Pluripotent Stem Cell Endothelial Cells","year":2018,"lang":"en","type":"letter","venue":"Circulation Genomic and Precision Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Induced pluripotent stem cell; Biology; Locus (genetics); Human Induced Pluripotent Stem Cells; Stem cell; Expression quantitative trait loci; Trait; Genetics; Quantitative trait locus; Cell biology; Embryonic stem cell; Gene; Computer science; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003993904,0.0003473488,0.0005475749,0.0002293713,0.0000835993,0.00001954287,0.0002071528,0.0006947462,0.00009184097],"category_scores_gemma":[0.00004237815,0.0003195824,0.00009277558,0.00008913806,0.0001742864,0.000007987947,0.00009938528,0.0003642641,0.000006762698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007853019,"about_ca_system_score_gemma":0.0001330871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941003,"about_ca_topic_score_gemma":0.00003608138,"domain_scores_codex":[0.9977403,0.0001854098,0.0008649798,0.0006217762,0.0003239856,0.0002635763],"domain_scores_gemma":[0.9984767,0.0001789559,0.0006331891,0.0004299408,0.0001965672,0.00008458104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001319365,0.00002766581,0.0001581376,0.0001368144,0.00002286841,0.000009458849,0.0005418328,0.0002461339,0.9468033,0.00001140812,0.05021128,0.001699207],"study_design_scores_gemma":[0.007998314,0.002354584,0.004067176,0.0009928661,0.0002518397,0.00002890874,0.0006026526,0.0008741226,0.6286882,0.0006612047,0.3523535,0.001126667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865656,0.002077999,0.004943252,0.003505209,0.0009602319,0.0008795869,0.0003371463,0.000009504368,0.0007215025],"genre_scores_gemma":[0.9842393,0.0008035714,0.0002363904,0.01062883,0.002348921,0.00002964172,0.001331386,0.00006499024,0.0003168992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3181151,"threshold_uncertainty_score":0.9999256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02633735647304427,"score_gpt":0.2734473169570781,"score_spread":0.2471099604840338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}