{"id":"W2895828633","doi":"10.1101/449363","title":"Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"Bundesministerium für Bildung und Forschung; University of Adelaide; National Institute of Mental Health; Deutsche Forschungsgemeinschaft","keywords":"Bipolar disorder; Major depressive disorder; Genome-wide association study; Lithium (medication); Internal medicine; Quartile; Depression (economics); Oncology; Single-nucleotide polymorphism; Treatment-resistant depression; Genetic association; Medicine; Psychology; Bioinformatics; Clinical psychology; Genotype; Genetics; Biology; Gene; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008638371,0.0004322109,0.0004283724,0.0006896878,0.0003228145,0.0005595317,0.0002921706,0.0004421599,0.001667487],"category_scores_gemma":[0.002300588,0.0002528655,0.001196396,0.001174699,0.0002066868,0.0002458709,0.0004092921,0.0004778721,0.0001264835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106226,"about_ca_system_score_gemma":0.0002181226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006207446,"about_ca_topic_score_gemma":0.007673518,"domain_scores_codex":[0.9993408,0.0002686091,0.00007395978,0.0001968396,0.00006438975,0.00005536321],"domain_scores_gemma":[0.9987942,0.0003505373,0.0005196866,0.000125602,0.00009777452,0.00011212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003648671,0.00001966204,0.9951615,0.00003461778,0.001332746,0.00004134176,0.00001961339,0.0001585423,0.0002946249,0.00002812198,0.0002216376,0.002322915],"study_design_scores_gemma":[0.00002546193,0.00005812996,0.9978197,0.00001215257,0.0006737874,0.00009177478,0.00002634263,0.001005404,0.00006108519,0.0001075905,0.0001145187,0.000004146403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958273,0.001967449,0.0005670224,0.0001642717,0.0000218955,0.00001261023,0.001074257,0.00001609627,0.0003491339],"genre_scores_gemma":[0.9991164,0.0001560408,0.0001789103,0.00002880343,0.00001212232,0.000006924085,0.0004296029,0.00000192395,0.00006929142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006207446,"threshold_uncertainty_score":0.01234263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005785086896767444,"score_gpt":0.2183122006018834,"score_spread":0.212527113705116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}