{"id":"W2895841717","doi":"10.1002/stem.2902","title":"Concise Review: TLR Pathway-miRNA Interplay in Mesenchymal Stromal Cells: Regulatory Roles and Therapeutic Directions","year":2018,"lang":"en","type":"review","venue":"Stem Cells","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Krembil Foundation; University Health Network","funders":"","keywords":"Biology; Mesenchymal stem cell; microRNA; Cell biology; Innate immune system; Stromal cell; Immune system; Signal transduction; Microvesicles; Toll-like receptor; Inflammation; Immunology; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004969373,0.0007840493,0.001101414,0.001691244,0.0002888371,0.001006689,0.0006920212,0.00118637,0.004606427],"category_scores_gemma":[0.0009223379,0.0002100645,0.0003939431,0.001562195,0.0003513478,0.001448975,0.000803989,0.001819763,0.002604521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004478541,"about_ca_system_score_gemma":0.001116583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003386952,"about_ca_topic_score_gemma":0.0006080174,"domain_scores_codex":[0.9998237,0.00002742091,0.00003529205,0.00003251528,0.00006359012,0.00001744542],"domain_scores_gemma":[0.9996215,0.0001373727,0.00005721759,0.000009626104,0.0001193131,0.00005494864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008806548,0.00005322363,0.0001299994,0.01986943,0.00008945529,0.0003590566,0.00007169813,0.0002504294,0.003607881,0.00401763,0.1130819,0.8583813],"study_design_scores_gemma":[0.00001029724,0.00005468266,0.0002555175,0.001696813,0.00008347521,0.00114557,0.00003354727,0.00005712338,0.0005848128,0.00115476,0.9949071,0.00001628744],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009312061,0.9963173,0.0002430286,0.0007990686,0.001550654,0.00000573354,0.00002868227,0.00001412235,0.0009482878],"genre_scores_gemma":[0.0006402737,0.9966916,0.0002403948,0.0005394592,0.0009775447,0.000008348386,0.00005528268,0.000003438265,0.0008437697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004606427,"threshold_uncertainty_score":0.01541001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672481050963295,"score_gpt":0.2878826235523876,"score_spread":0.2711578130427547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}