{"id":"W2895859833","doi":"10.3390/pharmaceutics10040196","title":"Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance","year":2018,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Cancer Foundation; Canadian Institutes of Health Research; Women and Children's Health Research Institute","keywords":"Cisplatin; Micelle; Chemistry; Cytotoxicity; Pharmacology; Cancer research; Biophysics; Biochemistry; In vitro; Chemotherapy; Biology; Organic chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570493,0.0003222125,0.0002195681,0.00007859887,0.00005518708,0.0001867031,0.0001690109,0.0002460786,0.0004984043],"category_scores_gemma":[0.0001286413,0.00009890116,0.0001661995,0.00007556742,0.000136338,0.0002421414,0.0001328632,0.0003061546,0.0001284036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001580031,"about_ca_system_score_gemma":0.00009826343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001967202,"about_ca_topic_score_gemma":0.0002560594,"domain_scores_codex":[0.9999021,0.00002456565,0.000009456922,0.00002323371,0.00002072688,0.00001995277],"domain_scores_gemma":[0.9999319,0.00001642121,0.00002220235,0.00000785723,0.00001020664,0.00001140882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004413892,0.00001755248,0.00004088385,0.0000235709,0.000003171266,0.00001393047,0.000006090755,0.00004798331,0.999065,0.0000293329,0.000008483785,0.0006998052],"study_design_scores_gemma":[0.00000986789,0.0003570481,0.0004301808,0.000001603311,0.00000826529,0.00006426725,0.000002832012,0.0004036988,0.9981362,0.000005154348,0.0005790355,0.000001911156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951835,0.001345662,0.002756501,0.00007340052,0.0000146188,0.00004268319,0.00004235584,0.00003100968,0.0005102177],"genre_scores_gemma":[0.9958493,0.0008012322,0.002379356,0.0000457617,0.00000866851,0.00003708193,0.00007769671,0.000009788351,0.0007911638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004984043,"threshold_uncertainty_score":0.00166738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648854454207877,"score_gpt":0.29361710787819,"score_spread":0.2771285633361112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}