{"id":"W2895859833","doi":"10.3390/pharmaceutics10040196","title":"Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance","year":2018,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Cancer Foundation; Canadian Institutes of Health Research; Women and Children's Health Research Institute","keywords":"Cisplatin; Micelle; Chemistry; Cytotoxicity; Pharmacology; Cancer research; Biophysics; Biochemistry; In vitro; Chemotherapy; Biology; Organic chemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003856599,0.0001441692,0.00028321,0.00004870653,0.00004363344,0.000002318189,0.0002294809,0.00009108763,0.000003687798],"category_scores_gemma":[0.0001495061,0.0001077587,0.000132493,0.0003375969,0.000269245,0.000005772484,0.00006716046,0.00006996212,2.596543e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001433773,"about_ca_system_score_gemma":0.00007867685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003635236,"about_ca_topic_score_gemma":0.00005352995,"domain_scores_codex":[0.9987415,0.0001351821,0.0004781804,0.000200119,0.0003048727,0.0001401091],"domain_scores_gemma":[0.9984271,0.0000785384,0.0006562193,0.0004915944,0.0003014584,0.00004506935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001342478,0.00003171508,0.000446883,0.0002465944,0.00006976949,2.025188e-8,0.0005870541,0.0001106081,0.9959278,0.00002481888,0.0002325395,0.000979699],"study_design_scores_gemma":[0.001359043,0.0001247385,0.002064589,0.0000577031,0.0001914621,2.217253e-7,0.00008238786,0.0001924264,0.9939681,0.0000134076,0.001854402,0.00009146731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956004,0.002807599,0.0001197174,0.00008006072,0.0006829257,0.0004192361,0.0001014301,0.000002530929,0.000186073],"genre_scores_gemma":[0.9990456,0.0004044112,0.0001577553,0.00002376087,0.0002527467,0.00001104191,0.0000178493,0.00001810206,0.00006872359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003445182,"threshold_uncertainty_score":0.4394273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648854454207877,"score_gpt":0.29361710787819,"score_spread":0.2771285633361112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}