{"id":"W2895868678","doi":"10.1016/j.jalz.2018.09.003","title":"AMYPAD Diagnostic and Patient Management Study: Rationale and design","year":2018,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Horizon 2020 Framework Programme; GE Healthcare; IXICO; H. Lundbeck A/S; Eisai; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biogen; European Federation of Pharmaceutical Industries and Associations; AbbVie; University College London Hospitals NHS Foundation Trust; European Commission; Sanofi; Deutsche Forschungsgemeinschaft; General Electric; Merck; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Novartis; Pfizer; Acadia University; Eli Lilly and Company","keywords":"Medicine; Dementia; Reimbursement; Clinical endpoint; Positron emission tomography; Randomized controlled trial; Neuroimaging; Disease; Intensive care medicine; Alzheimer's disease; Health care; Internal medicine; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06293312,0.002895023,0.003573617,0.001819855,0.0020203,0.002441633,0.003051864,0.003570505,0.01539595],"category_scores_gemma":[0.04063648,0.00191649,0.00220498,0.002758237,0.003213458,0.001706399,0.001731747,0.003106975,0.005163374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001692839,"about_ca_system_score_gemma":0.0102251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008166708,"about_ca_topic_score_gemma":0.001560888,"domain_scores_codex":[0.9632395,0.02719343,0.002338262,0.002363816,0.003866122,0.0009989303],"domain_scores_gemma":[0.986893,0.00434,0.002113937,0.002149214,0.00294344,0.001560385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.5605983,0.02729446,0.09011386,0.02894385,0.008381768,0.002668751,0.00213957,0.00591705,0.005423013,0.0460313,0.07459953,0.1478886],"study_design_scores_gemma":[0.513005,0.08952523,0.06039336,0.009433534,0.009306134,0.001754062,0.001017808,0.01176602,0.002993316,0.03734234,0.2628863,0.0005768906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.03041094,0.005980851,0.02057833,0.005362182,0.002382096,0.9167688,0.00887827,0.000151513,0.009486999],"genre_scores_gemma":[0.05778964,0.0013464,0.02263405,0.003792558,0.0007602909,0.9094257,0.002349739,0.00002380891,0.001877937],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06293312,"threshold_uncertainty_score":0.3328261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461722777421468,"score_gpt":0.3049570419169479,"score_spread":0.2703398141427332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}