{"id":"W2895869463","doi":"10.3389/fgene.2018.00440","title":"Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs","year":2018,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nuclear export signal; RNA splicing; Biology; Spliceosome; RNA; Long non-coding RNA; Intron; Cytoplasm; Cell biology; Cell nucleus; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002168068,0.0002692434,0.0004354655,0.0002561099,0.0001578408,0.0005625973,0.0002357815,0.0003326731,0.001436264],"category_scores_gemma":[0.000359092,0.0001117694,0.0002496235,0.0002838149,0.0004676759,0.000538398,0.0002582641,0.0005932853,0.001173384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003238929,"about_ca_system_score_gemma":0.0004026034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000188397,"about_ca_topic_score_gemma":0.0002624777,"domain_scores_codex":[0.9998374,0.00002449323,0.00001575483,0.00005407592,0.00004321559,0.00002496015],"domain_scores_gemma":[0.9998057,0.00006586805,0.00006475929,0.000007200213,0.0000355422,0.00002098714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002878722,0.00002612094,0.002984983,0.004307486,0.00005784781,0.002253272,0.0002834959,0.001053864,0.8021049,0.03382668,0.004857596,0.1479559],"study_design_scores_gemma":[0.00005351534,0.000544311,0.02851875,0.0008268781,0.0002148326,0.01037918,0.0006164875,0.002042382,0.3601377,0.02608781,0.570484,0.0000942316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2177556,0.7052225,0.04095444,0.00332103,0.001507715,0.00007029274,0.001140174,0.0003961208,0.02963209],"genre_scores_gemma":[0.5682497,0.4023525,0.01282585,0.0009631629,0.001207409,0.0000869583,0.001904238,0.0001658216,0.01224435],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001436264,"threshold_uncertainty_score":0.00480479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04507087167790842,"score_gpt":0.3294506433186332,"score_spread":0.2843797716407248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}