{"id":"W2895872316","doi":"10.1093/annonc/mdy281.157","title":"Phase I studies assessing the safety and clinical activity of multiple doses of a NKG2D-based CAR-T therapy, CYAD-01, in metastatic colorectal cancer","year":2018,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; European Regional Development Fund; Engineering and Physical Sciences Research Council; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Koning Boudewijnstichting; Cancer Research Foundation in Northern Sweden; Generalitat de Catalunya; Umeå Universitet; Vetenskapsrådet; Fondation contre le Cancer; Cancerfonden; McGill University","keywords":"Medicine; Chimeric antigen receptor; NKG2D; FOLFOX; Colorectal cancer; Oncology; Internal medicine; Clinical trial; Context (archaeology); Tumor microenvironment; Bevacizumab; Immunotherapy; Cancer; Chemotherapy; Oxaliplatin; Cytotoxic T cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001550786,0.001060956,0.001249019,0.0004573567,0.0003774705,0.0009646859,0.0007831965,0.001009778,0.003095881],"category_scores_gemma":[0.0007836313,0.0003564678,0.00099814,0.0004489455,0.0009590655,0.0006997142,0.0003107382,0.003112455,0.0006337835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144236,"about_ca_system_score_gemma":0.001964835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112391,"about_ca_topic_score_gemma":0.002426657,"domain_scores_codex":[0.9996177,0.0001598742,0.00002169855,0.00007688566,0.00003620129,0.00008758187],"domain_scores_gemma":[0.9991703,0.0001469126,0.0002085287,0.00008483275,0.00005840182,0.0003310967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5967369,0.08305816,0.008442653,0.00175085,0.001638616,0.0003835187,0.000418979,0.007279094,0.1373129,0.0009321519,0.006244755,0.1558014],"study_design_scores_gemma":[0.2405505,0.7251713,0.006975577,0.0000550317,0.0005519948,0.0004338431,0.00006780677,0.001297082,0.02065148,0.0002347525,0.003984252,0.00002632098],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908535,0.002315161,0.0009733881,0.0003499094,0.0001010217,0.001961391,0.001155957,0.0001175612,0.002172208],"genre_scores_gemma":[0.9882742,0.002144552,0.001762918,0.0004110809,0.0001016377,0.002496878,0.00214216,0.00004114125,0.002625346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003095881,"threshold_uncertainty_score":0.01035678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.335728840455008,"score_gpt":0.5838037167005191,"score_spread":0.2480748762455111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}