{"id":"W2895898846","doi":"10.1176/appi.ajp.2018.17040415","title":"Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects","year":2018,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Substance Abuse Treatment and Outcomes","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"David Geffen School of Medicine, University of California, Los Angeles; National Center for Complementary and Integrative Health; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Melbourne School of Psychological Sciences; National Health and Medical Research Council; Laureate Institute for Brain Research, University of Tulsa; Illawarra Health and Medical Research Institute; Max-Planck-Institut für Kognitions- und Neurowissenschaften; University of Cape Town; Janssen Research and Development; Radboud Universitair Medisch Centrum; Radboud Universiteit; Universitat de Barcelona; Vrije Universiteit Amsterdam; National Institute of Mental Health; University of Colorado Boulder; QIMR Berghofer Medical Research Institute; Universiteit Utrecht; ZonMw; School of Medicine; University of Vermont; Universiteit van Amsterdam; Monash University; Medical Research Council; University of Wollongong; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; University of Southern California; Australian Catholic University; Universiteit Leiden; University of Oregon; University of California, San Diego; Yale University; King's College London; Veterans Affairs San Diego Healthcare System; McGill University; University of Rochester; National Institutes of Health; San Diego State University","keywords":"Brain size; Cannabis; Substance dependence; Orbitofrontal cortex; Alcohol dependence; Neuroimaging; Insula; Cocaine dependence; Voxel-based morphometry; Substance abuse; Brain morphometry; Medicine; Psychology; Addiction; Magnetic resonance imaging; Psychiatry; Neuroscience; Alcohol; Prefrontal cortex; Cognition; White matter; Chemistry; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002055346,0.0004310581,0.0006361303,0.001769047,0.0003040325,0.0004289596,0.0004617997,0.0002309621,0.001754232],"category_scores_gemma":[0.003649177,0.0002322395,0.00102573,0.001342851,0.0004340467,0.0003105954,0.000982731,0.0002682109,0.0001399836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231758,"about_ca_system_score_gemma":0.0001758934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226001,"about_ca_topic_score_gemma":0.002572851,"domain_scores_codex":[0.9988759,0.000401095,0.00009982481,0.0003398805,0.0002153614,0.00006786796],"domain_scores_gemma":[0.9976168,0.0009553124,0.000572472,0.0005371434,0.0002210908,0.0000972276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002156388,0.00004037885,0.9528447,0.0001511267,0.004032296,0.0002417861,0.0002987978,0.0006966318,0.0211922,0.0001340525,0.0004654903,0.01774598],"study_design_scores_gemma":[0.00001165155,0.0002123702,0.995442,0.000006011985,0.0003362657,0.0002806433,0.00005150719,0.001142205,0.002183984,0.00006303683,0.0002660173,0.000004294221],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965956,0.0004691261,0.002204618,0.0000161688,0.000004108712,0.00002130707,0.0003944779,0.00005022583,0.0002443633],"genre_scores_gemma":[0.9968613,0.00005052588,0.00243066,0.000007514802,0.000003787378,0.00003489348,0.0004345882,0.00003487338,0.0001417539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055346,"threshold_uncertainty_score":0.01086986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135720845557507,"score_gpt":0.2714902986083927,"score_spread":0.2601330901528177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}