{"id":"W2895900900","doi":"10.1152/physiol.00026.2018","title":"Pluripotent Stem Cell-Derived Pancreatic Progenitors and β-Like Cells for Type 1 Diabetes Treatment","year":2018,"lang":"en","type":"review","venue":"Physiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Toronto General and Western Hospital Foundation; Juvenile Diabetes Research Foundation International","keywords":"Induced pluripotent stem cell; Progenitor cell; Stem cell; Cell; Cell type; SAFER; Pancreas; Biology; In vitro; Cell therapy; In vivo; Type 2 diabetes; Cell biology; Bioinformatics; Diabetes mellitus; Computational biology; Embryonic stem cell; Computer science; Biotechnology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008257056,0.0005120334,0.002306202,0.0001230453,0.00009954854,0.00001309873,0.00007731303,0.0003130009,0.00007442534],"category_scores_gemma":[0.00002353651,0.0003309803,0.0004070212,0.0001283366,0.0001649407,0.00002112276,0.00004815337,0.000102867,0.000200695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394031,"about_ca_system_score_gemma":0.0002368622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005597738,"about_ca_topic_score_gemma":3.485412e-7,"domain_scores_codex":[0.9982428,0.0001285837,0.0004447796,0.0006041262,0.00008642105,0.0004933224],"domain_scores_gemma":[0.9985421,0.00045418,0.0002664371,0.0004227762,0.0001117716,0.0002027351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003917356,0.001092941,0.0001150541,0.08107714,0.004165822,0.000007762899,0.0002896407,3.817086e-7,0.03835365,0.00002692202,0.009211424,0.8652675],"study_design_scores_gemma":[0.001234819,0.003285106,0.00004603145,0.00225994,0.004904415,0.000006833226,0.00003058313,0.00002975445,0.003903065,0.00002788951,0.9839262,0.0003453329],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04358423,0.9527471,0.000002106336,0.00001285164,0.0009409033,0.002357956,0.00006485631,0.00007856986,0.0002114108],"genre_scores_gemma":[0.0008228293,0.9939574,0.0003838149,0.0001024311,0.0007706757,0.0008799628,0.0003870031,0.00007789717,0.002617961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9747148,"threshold_uncertainty_score":0.9999142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06502439920473559,"score_gpt":0.3151709222581224,"score_spread":0.2501465230533869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}