{"id":"W2895909123","doi":"10.1101/424010","title":"Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Multiple System Atrophy Coalition; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; Wellcome Trust; Deutsche Forschungsgemeinschaft; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto; National Institute of Environmental Health Sciences; EU Joint Programme – Neurodegenerative Disease Research; Michael J. Fox Foundation for Parkinson's Research; American Parkinson Disease Association; Itä-Suomen Yliopisto; Institute of Genetics; National Institutes of Health; U.S. Department of Health and Human Services; McGill University; U.S. Department of Defense","keywords":"Genome-wide association study; Heritability; Genetic association; Missing heritability problem; Locus (genetics); Genetics; Age of onset; Biology; Disease; Bonferroni correction; Genetic variation; Genotype; Medicine; Single-nucleotide polymorphism; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002097068,0.0003710823,0.0007711822,0.0009623657,0.0003961707,0.0008541506,0.0002903977,0.0005834303,0.001740011],"category_scores_gemma":[0.004206041,0.0002934772,0.0009595873,0.00174346,0.0002862874,0.0003158778,0.0006966727,0.0006362285,0.0002253549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168164,"about_ca_system_score_gemma":0.000193632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004060992,"about_ca_topic_score_gemma":0.00471791,"domain_scores_codex":[0.9983268,0.0005598538,0.0001404787,0.000619296,0.0002139908,0.0001396484],"domain_scores_gemma":[0.9975683,0.0009788427,0.0006140663,0.0004050407,0.0002466635,0.0001870354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003661297,0.00002683454,0.9840112,0.0001127226,0.002378118,0.0004690409,0.0001611558,0.0003941363,0.005599947,0.0002473591,0.0007382476,0.005495113],"study_design_scores_gemma":[0.00002226551,0.00006442753,0.9969848,0.00002197962,0.0007518285,0.0004199948,0.00006594518,0.0005175261,0.0002709891,0.0002238381,0.0006499647,0.000006492971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876545,0.003652282,0.004431722,0.0002079795,0.00005967254,0.00003145811,0.002737167,0.00009431537,0.001130892],"genre_scores_gemma":[0.9977708,0.0003291916,0.0007065574,0.00006520154,0.00002925545,0.00001569885,0.0008914911,0.00002116284,0.0001706879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004060992,"threshold_uncertainty_score":0.01109052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580654721549585,"score_gpt":0.2341357538833357,"score_spread":0.2183292066678398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}